Evidence map›Paper›PMID 40469689›Full record

ArticleCurrent therapeutic research, clinical and experimental2025

Relationship Between Dietary Acid Load and Risk of Metastatic Colorectal Cancer: A Case-Control Study.

Fatemeh Babaee Kiadehi, Niayesh Naghshi, Fatemeh Farz, Pedram Pam, Arash Tandorost, Alireza Ostadrahimi, Reza Eghdam Zamiri

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In one paragraph

Article in Current therapeutic research, clinical and experimental, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fatemeh Babaee KiadehiDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Niayesh NaghshiDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Fatemeh FarzFaculty of Medical School, Najafabad branch, Islamic Azad University, Isfahan, Iran.
Pedram PamStudent Research Committee, Urmia University of Medical Sciences, Urmia, Iran.
Arash TandorostFaculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Alireza OstadrahimiFaculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Reza Eghdam ZamiriDepartment of Radiation Oncology, Tabriz University of Medical Sciences, Tabriz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Colorectal cancer (CRC) is a type of cancer affecting the colon and rectum, primarily originating from intestinal polyps. Recently, increasing attention has been given to the role of dietary acid-base balance in cancer development. This study aimed to investigate the relationship between dietary acid load and the risk of metastatic colorectal cancer (mCRC). Design/methodology/approach: This hospital-based case-control study was conducted on 120 adults with mCRC and 240 non-neoplastic adults in the control group, matched for age and gender. Dietary intake was assessed using a food frequency questionnaire. Net endogenous acid production (NEAP) and potential renal acid load (PRAL) were calculated using predetermined formulas. Odds ratios (ORs) were used to estimate the risk of mCRC across PRAL and NEAP tertiles. Findings: There were no significant differences between the two groups in terms of demographic characteristics, anthropometric measures, smoking, and alcohol consumption. However, energy intake and energy-adjusted carbohydrate, fiber, potassium, magnesium, and calcium intake were significantly higher in the control group compared to the case group ( Originality/value: High PRAL levels were associated with an increased risk of mCRC, whereas NEAP scores were not linked to mCRC risk.

Indexed as

Dietary acid loadEndogenous net acid productionMetastatic colorectal cancerRenal acid load potential

Identifiers

PMID40469689
PMCPMC12134544

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.