Evidence map›Paper›PMID 40469771›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2025

Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring.

Chandra Mohan Reddy Muthumula, Yaswanthi Yanamadala, Kuppan Gokulan, Kumari Karn, Helen Cunny, Vicki Sutherland, Janine H Santos, Sangeeta Khare

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Realizing Impact of Artificial Intelligence in Real World Enhances Public Health.Experimental biology and medicine (Maywood, N.J.) · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chandra Mohan Reddy Muthumula *Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, United States.
Yaswanthi Yanamadala *Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, United States.
Kuppan GokulanDivision of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, United States.
Kumari KarnDivision of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, United States.
Helen CunnyDivision of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States.
Vicki SutherlandDivision of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States.
Janine H SantosDivision of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States.
Sangeeta KhareDivision of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the highly effective impact of antiretroviral therapy (ART) in reducing mother-to-child transmission of human immunodeficiency virus (HIV), there are concerns of long-term impacts of ART on the health of the offspring. The implications of perinatal exposure to antiviral drugs on the gut bacterial population and metabolic function in the offspring is unclear but may influence health outcomes given the various reported effects of the microbiome in human health. This study aims to gain insight into the potential effect of

Indexed as

Anti-Retroviral AgentsGastrointestinal MicrobiomeLactationPrenatal Exposure Delayed EffectsAnimalsFatty Acids, VolatileFecesFemaleMalePregnancyRatsAnti-Retroviral AgentsFatty Acids, Volatileantiretroviral therapyIgAintestine, fecalmicrobiomeperinatal exposureshort-chain fatty acids

Identifiers

PMID40469771
PMCPMC12135209

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.