Evidence map›Paper›PMID 40469835›Full record

ArticleJournal of the Endocrine Society2025

Safety and Effectiveness of Oral Glyburide Suspension in Neonatal Diabetes Mellitus: French Retrospective Cohort Study.

Ines Ben Rhaiem, Jacques Beltrand, Gaëlle Vermillac, Dulanjalee Kariyawasam, Delphine Geraud, Alix Besançon, Cécile Godot, Marianne Berdugo, Adeline Alice Bonnard, Hélène Cavé and 16 more

Abstract read
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Article in Journal of the Endocrine Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Ines Ben RhaiemPediatric Endocrinology, Gynecology, and Diabetology Department, Necker-Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, ENDO-ERN (European Reference Network) and PRISIS French National Rare Disorder Centre (Rare Disorders of Insulin Secretion and Sensitivity), 75015 Paris, France.
Jacques BeltrandPediatric Endocrinology, Gynecology, and Diabetology Department, Necker-Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, ENDO-ERN (European Reference Network) and PRISIS French National Rare Disorder Centre (Rare Disorders of Insulin Secretion and Sensitivity), 75015 Paris, France.ORCID https://orcid.org/0000-0002-3759-3490
Gaëlle VermillacPediatric Endocrinology, Gynecology, and Diabetology Department, Necker-Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, ENDO-ERN (European Reference Network) and PRISIS French National Rare Disorder Centre (Rare Disorders of Insulin Secretion and Sensitivity), 75015 Paris, France.
Dulanjalee KariyawasamPediatric Endocrinology, Gynecology, and Diabetology Department, Necker-Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, ENDO-ERN (European Reference Network) and PRISIS French National Rare Disorder Centre (Rare Disorders of Insulin Secretion and Sensitivity), 75015 Paris, France.ORCID https://orcid.org/0000-0002-3870-202X
Delphine GeraudDepartment of Pediatrics, Arcachon Hospital, 33260 La Teste-de-Buch, France.
Alix BesançonPediatric Endocrinology, Gynecology, and Diabetology Department, Necker-Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, ENDO-ERN (European Reference Network) and PRISIS French National Rare Disorder Centre (Rare Disorders of Insulin Secretion and Sensitivity), 75015 Paris, France.
Cécile GodotPediatric Endocrinology, Gynecology, and Diabetology Department, Necker-Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, ENDO-ERN (European Reference Network) and PRISIS French National Rare Disorder Centre (Rare Disorders of Insulin Secretion and Sensitivity), 75015 Paris, France.
Marianne BerdugoUniversité Paris Cité, 75006 Paris, France.
Adeline Alice BonnardUniversité Paris Cité, 75006 Paris, France.
Hélène CavéUniversité Paris Cité, 75006 Paris, France.
Sylvie Nivot-AdamiakPediatric Emergency and Specialties Department, Rennes University Hospital, 35033 Rennes, France.
Marie Béatrice SaadePediatric Emergency and Specialties Department, Rennes University Hospital, 35033 Rennes, France.
Virginie RibaultPediatric Medical Department, Caen University Centre, 14000 Caen, France.
Sabine BaronPediatric Medicine Department, Nantes University Hospital, 44000 Nantes, France.
Cécile Petit-BibalPaediatric Endocrinology and Diabetology Department, Kremlin-Bicêtre University Hospital, 94270 Le Kremlin-Bicêtre, France.
Fabienne Dalla-ValeMultidisciplinary Pediatrics Department, Montpellier University Hospital, 34000 Montpellier, France.
Karine BourdetBrest Pediatrics Department, Brest University Hospital, 29609 Brest, France.
Carole MorinGastro-enterology, Hepatology, Nutrition, and Diabetology Department, Purpan University Centre, 31300 Toulouse, France.
Aurélie DonzeauPediatrics Department, Angers University Hospital, 49100 Angers, France.
Iva GueorguievaPediatric Endocrinology Department, Jeanne de Flandre Hospital, Lille University Hospital, 59037 Lille, France.ORCID https://orcid.org/0000-0002-3562-6973
Pierre-François SouchonDepartment of General and Specialized Pediatrics, Reims University Hospital, 51100 Reims, France.
Marc NicolinoPediatric Endocrinology, Diabetology, and Inherited Metabolic Disorders Department, Lyon Hospices Civils University Hospital, 69677 Bron, France.
Pascal BaratPaediatric Endocrinology, Diabetology, Gynecology, and Obesity Department, Bordeaux University Hospital, 33076 Bordeaux, France.
Régis CoutantPediatrics Department, Angers University Hospital, 49100 Angers, France.
Kevin PergePediatric Endocrinology, Diabetology, and Inherited Metabolic Disorders Department, Lyon Hospices Civils University Hospital, 69677 Bron, France.ORCID https://orcid.org/0000-0002-6527-805X
Michel PolakPediatric Endocrinology, Gynecology, and Diabetology Department, Necker-Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, ENDO-ERN (European Reference Network) and PRISIS French National Rare Disorder Centre (Rare Disorders of Insulin Secretion and Sensitivity), 75015 Paris, France.ORCID https://orcid.org/0000-0003-2639-352X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Context: Neonatal diabetes mellitus (NDM) is a rare condition usually related to an identifiable genetic cause. Sulfonylurea therapy can ensure metabolic control, obviating the need for insulin while also improving neurodevelopmental outcomes. An oral glyburide suspension (OGS; AMGLIDIA) designed for pediatric use was introduced recently to eliminate the drawbacks of using crushed tablets. Objective: To evaluate the long-term effectiveness and safety of the OGS for NDM. Design: Retrospective cohort study. Setting: Fifteen centers in France. Patients: Consecutive patients started on OGS for NDM in 2015 through 2024. Intervention: OGS therapy. Main outcome measures: Glycated hemoglobin (HbA1c) values during OGS therapy; growth; and serious adverse events. Results: Of 27 patients, 22 had Conclusion: The OGS was effective in maintaining excellent metabolic control in the long term. The safety profile was good. The OGS should be considered for the first-line treatment of NDM.

Indexed as

AMGLIDIAK-ATP channelslong-term efficacyneonatal diabetes mellituspediatric oral glyburide suspensionsafety

Identifiers

PMID40469835
PMCPMC12134890

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.