Evidence map›Paper›PMID 40470176›Full record

ArticleResearch square2025

LAP-Hsp60 complex modulates epithelial tight junction barrier.

Manalee Samaddar, Chen Sun, Nicholas L F Gallina, Nicole Irizarry-Tardi, Dongqi Liu, Shivendra Tenguria, Rishi Drolia, Anika Jain, Daisuke Kihara, Wen Jiang and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Chaperonin in health and disease.Molecular biomedicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Manalee SamaddarMolecular Food Microbiology Laboratory, Department of Food Science, Purdue University, West Lafayette, IN, USA.
Chen SunPurdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, IN, USA.
Nicholas L F GallinaMolecular Food Microbiology Laboratory, Department of Food Science, Purdue University, West Lafayette, IN, USA.
Nicole Irizarry-TardiMolecular Food Microbiology Laboratory, Department of Food Science, Purdue University, West Lafayette, IN, USA.
Dongqi LiuMolecular Food Microbiology Laboratory, Department of Food Science, Purdue University, West Lafayette, IN, USA.
Shivendra TenguriaMolecular Food Microbiology Laboratory, Department of Food Science, Purdue University, West Lafayette, IN, USA.
Rishi DroliaMolecular Food Microbiology Laboratory, Department of Food Science, Purdue University, West Lafayette, IN, USA.
Anika JainPurdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, IN, USA.
Daisuke KiharaPurdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, IN, USA.
Wen JiangPurdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, IN, USA.ORCID 0000-0002-1292-2411
Kee-Hong KimPurdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, IN, USA.
Abigail CoxPurdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, IN, USA.ORCID 0000-0003-2262-8168
Kurt D RistrophDepartment of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN, USA.
Gregory T KnippPurdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, IN, USA.
Nicholas NoinajPurdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, IN, USA.ORCID 0000-0001-6361-2336
Arun K BhuniaMolecular Food Microbiology Laboratory, Department of Food Science, Purdue University, West Lafayette, IN, USA.ORCID 0000-0003-3640-1554

Funding

Building protein structure models for intermediate resolution cryo-electron microscopy mapsR01GM133840 · NIGMS · PURDUE UNIVERSITY · PI KIHARA, DAISUKE · 2020 to 2023
$1.6M
NIGMS NIH HHS R01 GM133840
6 · The paper itself

Abstract

During infection,

Indexed as

cryo-EMHsp60LAPmousepeptide drug deliverystructure-functiontight junction modulator

Identifiers

PMID40470176
PMCPMC12136220

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.