Evidence map›Paper›PMID 40470204›Full record

ArticleResearch square2025

Calcium channel-coupled transcription factors facilitate direct nuclear signaling.

Eshaan R Rao, Tyler Thaxton, Eric Gama, Jack Godfrey, Cenfu Wei, Qiaoshan Lin, Yan Li, Daniel Parviz Hejazi Pastor, Christian Hansel, Xiaofei Du and 1 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Eshaan R RaoDepartment of Neurology, University of Chicago, Chicago, IL 60637, USA.
Tyler ThaxtonDepartment of Neurology, University of Chicago, Chicago, IL 60637, USA.
Eric GamaDepartment of Neurology, University of Chicago, Chicago, IL 60637, USA.
Jack GodfreyDepartment of Neurology, University of Chicago, Chicago, IL 60637, USA.
Cenfu WeiDepartment of Neurology, University of Chicago, Chicago, IL 60637, USA.
Qiaoshan LinCenter for Research Informatics, University of Chicago, IL 60637, USA.ORCID 0000-0001-7851-6048
Yan LiCenter for Research Informatics, University of Chicago, IL 60637, USA.ORCID 0000-0002-9481-8086
Daniel Parviz Hejazi PastorDepartment of Neurology, University of Chicago, Chicago, IL 60637, USA.
Christian HanselDepartment of Neurobiology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0001-5750-7097
Xiaofei DuDepartment of Neurology, University of Chicago, Chicago, IL 60637, USA.
Christopher M GomezDepartment of Neurology, University of Chicago, Chicago, IL 60637, USA.

Funding

Demystifying Disorders of Bicistronic Calcium Channel GenesR35NS116868 · NINDS · UNIVERSITY OF CHICAGO · PI Christopher Manuel Gomez · 2020 to 2026
$7.5M
A novel role for a bicistronic calcium channel gene in neurodevelopment and neurodegenerationR01NS082788 · NINDS · UNIVERSITY OF CHICAGO · PI GOMEZ, CHRISTOPHER MANUEL · 2014 to 2019
$2.8M
Overlapping cistrons in a family of ion channel genesR01NS094665 · NINDS · UNIVERSITY OF CHICAGO · PI GOMEZ, CHRISTOPHER MANUEL · 2015 to 2019
$2.1M
NINDS NIH HHS R01 NS082788NINDS NIH HHS R01 NS094665NINDS NIH HHS R35 NS116868
6 · The paper itself

Abstract

VGCCs play crucial roles within the CNS, in maintaining cell excitability, enabling activity-dependent neuronal development, and forming long-term memory by regulating Ca

Indexed as

bicistronic cellular genesCa2+ signalingCACNA1ACACNA1CCACNA1HC-terminal proteinsneuronal differentiationsynaptic functionVGCCVoltage-gated Ca2+ channelsα1ACTα1CCTα1HCT

Identifiers

PMID40470204
PMCPMC12136203

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.