Evidence map›Paper›PMID 40470323›Full record

ArticleInnovation (Cambridge (Mass.))2025

Ozone exposure and increased risk of age-related macular degeneration: Evidence from nationwide cohort and toxicological studies.

Guanran Zhang, Yanlin Qu, Xiaoling Wan, Xinyi Fang, Yidong Wu, Tong Li, Junran Sun, Xinxin Liu, Yanyi Xu, Huihuan Luo and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Innovation (Cambridge (Mass.)), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Guanran ZhangDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
Yanlin QuDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
Xiaoling WanDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
Xinyi FangSchool of Public Health, Fudan University, Shanghai 200032, China.
Yidong WuDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
Tong LiDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
Junran SunDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
Xinxin LiuDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
Yanyi XuSchool of Public Health, Fudan University, Shanghai 200032, China.
Huihuan LuoSchool of Public Health, Fudan University, Shanghai 200032, China.
Xia MengSchool of Public Health, Fudan University, Shanghai 200032, China.
Weiting HuShanghai Phoebus Medical Co., Ltd., Shanghai 200070, China.
Renjie ChenSchool of Public Health, Fudan University, Shanghai 200032, China.
Zhenyu WuSchool of Public Health, Fudan University, Shanghai 200032, China.
Huixun JiaDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
Xiaodong SunDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evidence regarding the impact of ozone on age-related macular degeneration (AMD) remains limited. We conducted a nationwide cohort analysis of 27,923 participants in China, along with a random control animal toxicological study, to elucidate the temporal relationship between ozone exposure and AMD as well as the underlying biological explanation. In the population study, 5,149 participants were diagnosed with incident AMD during a 348,701 person-month follow-up. The participants were divided into low-, medium-, and high-exposure groups. Fully adjusted Cox regression models showed that the risk of AMD increased by 28% for the medium- and 101% for the high-exposure groups relative to the low-exposure group (

Indexed as

age-related macularair pollutioncohortozone

Identifiers

PMID40470323
PMCPMC12131036

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.