ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Preoperative conversion therapy of camrelizumab combined with paclitaxel and nedaplatin for unresectable advanced esophageal squamous cell carcinoma: a phase 2 study.BMC medicine · 2025Trial
- Review
- Lactylation Modification and Esophageal Cancer: Research Progress From Hypoxia-Induced Metabolic Reprogramming to Immune Escape.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Lactate metabolism and protein lactylation in inflammatory and tumor microenvironments.Molecular biomedicine · 2026Review
- Glucose Transporter 1 in Health and Disease.MedComm · 2026Review
- Review
- Functional Role of ALKBH5 in Kidney Injury: Insights Into Mechanisms and Therapeutic Potential.Journal of cellular biochemistry · 2026Review
- Interplay between N6-methyladenosine RNA methylation and protein lactylation: a novel crosstalk linking metabolism and epigenetic regulation in human diseases.Journal of translational medicine · 2026Review
- Crosstalk between lactylation and other post-translational modifications in health and diseases.Molecular biomedicine · 2026Review
- Clinical implications of lactylation modification in digestive system tumors (Review).Oncology letters · 2026Review
- The MPK6-WRKY49 module links MAPK signaling to ABA biosynthesis and drought tolerance in Arabidopsis.The Plant journal : for cell and molecular biology · 2026Article
- Identification ofTranslational cancer research · 2026Article
- WTAP stabilizes MMP12 expression to promote the malignant phenotypes of esophageal cancer cells.Regenerative therapy · 2026Article
- METTL3 in esophageal cancer: Current insights into molecular mechanisms, subtype heterogeneity and targeted therapy prospects (Review).International journal of oncology · 2026Review
- A tumor microenvironment-focused signature based on m6A and lactylation modification predicts prognosis and immunotherapy response in hepatocellular carcinoma.Discover oncology · 2026Article
- Targeting WTAP/ROR1/WNT5A-Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- RNA modification-mediated multidimensional crosstalk: a novel perspective on gene expression regulation.Genome biology · 2026Review
- Histone lactylation-driven feedback loop modulates pyrimidine metabolism to promote oral carcinogenesis.Cell death & disease · 2026Article
- Histone H4K8 lactylation modulated immunosuppressive properties by promoting FAP transcription and ECM remodeling.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026Article
- RNA Methylation in Cancer Metabolism: from Mechanisms to Therapeutic Opportunities.International journal of biological sciences · 2026Review
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Authors and funding
14 authors.
Funding
Abstract
Esophageal squamous cell carcinoma (ESCC) is a common digestive tract malignant cancer with high incidence and mortality rate. Many studies have shown that long noncoding RNAs (lncRNAs are involved in the progression of various types of tumors. The lncRNA protein disulfide isomerase family A member 3 pseudogene 1 (PDIA3P1) promotes the progression of ESCC, but the molecular mechanism behind this is still unclear. In this study, PDIA3P1 is highly expressed in ESCC, produces more lactate by regulating glycolysis, and the increased lactate upregulates lactylation levels to drive tumor progression. Mechanistically, PDIA3P1 competes with miR-152-3p to prevent degradation of glucose transporter 1 (GLUT1) mRNA, and disrupts the binding between membrane-associated RING-CH 8 (MARCH8) and hexokinase 2 (HK2) to reduce ubiquitination degradation of HK2, thereby promoting glycolysis. High activity glycolysis produces more lactate, which upregulates the level of histone H4K8 lactylation (H4K8la) and promotes the transcription of target bone morphogenic protein 7 (BMP7). Functionally, BMP7 is involved in the regulation of ESCC progression by PDIA3P1 both in vivo and in vitro. In addition, wilms tumor 1-associated protein (WTAP) mediated m6A modification enhances the stability of PDIA3P1 through Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) dependent recognition. Taken together, these findings reveal the key role of PDIA3P1 regulates glycolysis-H4K8la-BMP7 axis in the progression of ESCC and provides new insights into the interplay between metabolic reprogramming and epigenetic regulation.
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