Evidence map›Paper›PMID 40473461›Full record

ReviewJournal of nuclear medicine : official publication, Society of Nuclear Medicine2025

Meeting Upcoming Clinical and Diagnostic Needs in Oncologic Imaging: A Structured Reporting System for Fibroblast-Activation-Protein-Targeted Imaging-FAP-RADS Version 1.0.

Emil Novruzov, Gabriel T Sheikh, Eduards Mamlins, Adrien Holzgreve, Yuriko Mori, Stephan Ledderose, Frederik Klauschen, Tadashi Watabe, Michael A Gorin, Martin G Pomper and 4 more

Abstract readReview
In one paragraph

Review in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Clinical performance of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. [RMD open · 2026
    Article
  7. Review
  8. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Emil NovruzovDepartment of Nuclear Medicine, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany; emil.novruzov@med.uni-duesseldorf.de.
Gabriel T SheikhDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Eduards MamlinsDepartment of Nuclear Medicine, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany.
Adrien HolzgreveDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Yuriko MoriDepartment of Nuclear Medicine, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany.
Stephan LedderoseInstitute of Pathology, Ludwig Maximilians University Munich, Germany.
Frederik KlauschenInstitute of Pathology, Ludwig Maximilians University Munich, Germany.
Tadashi WatabeDepartment of Radiology, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Michael A GorinMilton and Carroll Petrie Department of Urology, Icahn School of Medicine at Mount Sinai, New York, New York.
Martin G PomperDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas.
Ken HerrmannDepartment of Nuclear Medicine, University of Duisburg-Essen, Essen, Germany; German Cancer Consortium, University Hospital Essen, Essen, Germany.
Steven P RoweDepartment of Radiology, University of North Carolina, Chapel Hill, North Carolina.
Rudolf A WernerDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Frederik L GieselDepartment of Nuclear Medicine, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibroblast activation protein (FAP)-targeted imaging has emerged as a promising diagnostic tool for various oncologic and nononcologic conditions. However, the increasing employment of FAP-targeted imaging with small-molecule radiotracers mandates a standardized reporting system to ensure consistent interpretation across various clinical scenarios, especially in oncologic imaging. This study proposes an FAP reporting and data system (RADS) framework (FAP-RADS version 1.0) to address those needs, aiming to standardize FAP-targeted imaging reports, improve clinical communication, and support multicenter research.

Indexed as

GelatinasesMembrane ProteinsMolecular ImagingNeoplasmsSerine EndopeptidasesEndopeptidasesFibroblast Activation Protein AlphaHumansEndopeptidasesFibroblast Activation Protein AlphaGelatinasesMembrane ProteinsSerine EndopeptidasesFAPIFAP PETFAP-RADSFAP-targeted imagingRADS frameworkstandardized reporting

Identifiers

PMID40473461
PMCPMC12320583

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.