Evidence map›Paper›PMID 40474076›Full record

ArticleBMC genomics2025

Mutual suppression between mutations in the Dictyostelium Greenbeard pathway restores wild-type development.

Mariko Katoh-Kurasawa, Lena Trnovec, Peter Lehmann, Blaž Zupan, Gad Shaulsky

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In one paragraph

Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mariko Katoh-KurasawaDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Lena TrnovecFaculty of Computer and Information Science, University of Ljubljana, Ljubljana, Slovenia.
Peter LehmannDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Blaž ZupanDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Gad ShaulskyDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. gadi@bcm.edu.

Funding

The molecular basis of allorecognition and its roles in development and evolution of the social amoeba D. discoideumR35GM118016 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI SHAULSKY, GAD · 2016 to 2020
$2.1M
Mechanistic analysis of a pathway that integrates allorecognition and altruism in DictyosteliumR35GM152113 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI GAD SHAULSKY · 2024 to 2026
$1.4M
NIGMS NIH HHS R35 GM118016NIGMS NIH HHS R35 GM152113The Slovenian Research and Innovation Agency L2-60154
6 · The paper itself

Abstract

backgroundThe Dictyostelium greenbeard pathway is mediated by two polymorphic transmembrane proteins, the TgrC1 ligand and the TgrB1 receptor. These proteins mediate allorecognition, altruism, and the developmental transition to multicellularity. A genetic suppressor screen revealed activating mutations in tgrB1 and inactivating mutations in rapgapB, a regulator of the GTPase protein RapA. Inactivation of either tgrB1, tgrC1, or rapgapB leads to developmental defects, but the respective double-mutant strains rapgapB

resultsHere, we show that the mutual suppression between rapgapB

conclusionsThese findings suggest that the Dictyostelium greenbeard pathway interfaces with the central RapGAPB-RapA regulatory pathway, providing molecular insight into a mutual suppression mechanism in which two deleterious mutations restore wild-type behavior.

Indexed as

DictyosteliumMutationProtozoan ProteinsGTPase-Activating ProteinsSignal TransductionGTPase-Activating ProteinsProtozoan ProteinsDictyostelium allorecognitionDictyostelium developmentGreenbeard pathwayMutual suppressionTranscriptome phenotyping

Identifiers

PMID40474076
PMCPMC12142906

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.