SynthesisJournal of sleep research2026
Effects of Experimental Sleep Deprivation on Peripheral Inflammation: An Updated Meta-Analysis of Human Studies.
Synthesis in Journal of sleep research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of Experimental Sleep Deprivation on Peripheral Inflammation: An Updated Meta-Analysis of Human Studies.Journal of sleep research · 2026Pooled it
- Acute Sleep Deprivation Is Associated with Altered F-Wave Temporal Dynamics and Nasalis Repetitive Nerve Stimulation Responses: A Paired Electrophysiological Study.Brain sciences · 2026Article
- Article
- Dietary Carotenoid Intake and Sleep: A Narrative Review of Evidence from Human and In Vivo Animal Studies.Nutrients · 2026Review
- Association between changes in sleep quality and serum pro-inflammatory cytokine levels in patients with major depressive disorder following duloxetine treatment.Annals of general psychiatry · 2026Article
- Peripheral and central immune features in insomnia: Integrative bulk and single-cell transcriptomic analyses reveal core hub genes and candidate compounds.Functional & integrative genomics · 2026Article
- Chronic REM Sleep Deprivation Induces Metabolic and Neurotoxic Alterations Associated with Affective and Cognitive Deficit in Male Wistar Rats: Involvement of HPA Axis, Cholinergic, Inflammatory, and Oxidative Stress Pathways.Neurochemical research · 2026Article
- Sleep quality, duration, and multi-trajectories as predictors of rheumatoid arthritis: evidence from the english longitudinal study of ageing.Arthritis research & therapy · 2026Article
- The relationship between serum inflammatory cytokine levels and subjective sleep quality in chronic insomnia disorder.BMC psychiatry · 2026Article
- Comparative neuroprotective and exercise capacity effects of prophylactic intermittent fasting and probiotics in sleep-deprived rats: insights into anti-inflammatory marker modulation andFrontiers in pharmacology · 2026Article
- Inflammatory Cytokine-Mediated Interactions Between Pain and Insomnia: Mechanisms and Therapeutic Implications.Journal of pain research · 2026Review
- Sleep Disturbances and Sarcopenia in Older Adults: Clinical Associations, Potential Mechanisms, and Management Strategies.International journal of general medicine · 2026Review
- A [Journal of neuroinflammation · 2025Article
- Sleep Duration Modifies the Association of the Alternate Mediterranean Diet Score With Metabolic Syndrome in Midlife Women in Mexico.The Journal of nutrition · 2025Article
- Generalized Anxiety Disorder and Obesity: Overlapping Neuroendocrine, Metabolic, and Behavioral Pathways.Nutrients · 2025Review
- The severity of depressive symptoms as a mediator in the sleep-osteoarthritis risk pathway: insights from the ELSA cohort.Frontiers in nutrition · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A precise understanding of the effects of experimental sleep deprivation on inflammation is necessary to refine theoretical perspectives on sleep-related immunopathological processes and implement robust empirical procedures. Here, we report an updated preferred reporting items for systematic reviews and meta-analysis systematic review and meta-analysis testing the effects of experimental total and partial sleep deprivation on circulating inflammatory markers in healthy adult individuals. PubMed, Scopus, PsycINFO, and CINAHL were searched up to March 2025. Data were analysed using the DerSimonian and Laird random effects approach. Of the 2264 articles retrieved, we included 35 studies reporting on 887 participants. Compared to normal sleep, multiple nights of experimental partial sleep deprivation (sleep duration reduced to ~4.30 h for 3+ nights) were associated with a significant increase of interleukin-6 [IL-6, k = 5, d = 0.42, [95% CI = 0.11 to 0.73], p < 0.01] and C-reactive protein [CRP, k = 5, d = 0.76, [95% CI = 0.09 to 1.43], p = 0.03] in blood. A single night of total or partial sleep deprivation was not associated with changes in inflammation. Results suggest that the upregulation of inflammatory proteins in blood may only manifest following persistent periods of partial sleep deprivation. Further research will be needed to determine whether sleep recovery strategies (e.g., naps, sleep extension) may restore immune homeostasis. We suggest that experimental partial sleep deprivation for at least 3 nights may elicit peripheral IL-6 and CRP and could therefore serve as a valid procedure to study sleep-related immunopathological processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.