ReviewDevelopmental neurobiology2025
GATA Transcription Factors: A Cross-Road for Erythropoiesis, Neurodevelopment, and Synucleinopathies.
Review in Developmental neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Identification and validation of lactylation-related diagnostic biomarkers for type 2 diabetes by WGCNA.Journal of clinical biochemistry and nutrition · 2026Article
- Molecular characterization and expression analysis of GATA1 in the blood clam Anadara granosa reveals its role in gonadal development.BMC genomics · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
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Abstract
Alpha-synuclein (α-syn), a 140 amino acid protein, is abundantly expressed in the central nervous system (CNS) and in the erythrocytes, playing a pivotal role in the pathogenesis of Parkinson's disease (PD) and other synucleinopathies. Among the GATA family transcription factors (TFs), GATA1 and GATA2 regulate the meg-erythrocytic differentiation starting from the hematopoietic stem cell. In erythropoiesis, the GATA1-2 switching regulates the expression of the α-syn gene (SNCA) in the erythrocytes, which is essential for iron metabolism and membrane stability. Abnormalities in α-syn regulation alter erythrocytic function, possibly contributing to pathological mechanisms of different synucleinopathies. In CNS, during neuronal development, GATA2 confirms its role in stemness by maintaining the ventral neuronal progenitors and also leading GABAergic, serotoninergic, and sympathetic neuron differentiation. Therefore, although no evidence is reported regarding a direct role of GATA1 in neuronal lineage, GATA3 recruitment and activation are essential for the maturation of specific neuronal subtypes. This short scope review explores the bridging role of GATA TFs in erythropoiesis and neuronal development, highlighting their involvement in α-syn regulation, as well as their potential role in the pathogenesis of synucleinopathies.
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