ReviewFrontiers in pharmacology2025
Food plants as adjuvant medicines: a review of protective effects and clinical potential in alcoholic liver disease.
Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Iron-Sulfur Cluster Targeting: A Novel Perspective for Treating Alcohol-Related Lipid Metabolic Diseases.Journal of biochemical and molecular toxicology · 2026Review
- Natural Alkaloids Against Liver Injury: Mechanistic Insights and Multi-Target Therapeutic Potential.Biomolecules · 2026Review
- The zebrafish model: a versatile platform for uncovering the therapeutic potential of phytochemicals in liver diseases.Frontiers in pharmacology · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Research background: Globally, alcohol usage is the third-leading risk factor for diseases, and alcohol-induced alcoholic liver disease (ALD) has become a global public health problem. ALD is characterized by oxidative stress and immune damage in the liver caused by excessive alcohol consumption. Furthermore, alcohol and its metabolites disrupt the health of the intestinal tract and cause secondary liver damage through the gut-liver axis. Existing problems: The underlying mechanisms of ALD are complex. Currently, there are no safe and effective drugs for the prevention and treatment of ALD; some food plants used as medicines (FPUM) have demonstrated promising effects in combating this condition. Solutions: In this review, we analyze the pathogenesis of ALD and explore the mechanisms of action of certain FPUM in preventing and treating ALD. Different mechanisms include activation of alcohol metabolism-related enzymes, maintenance of mitochondrial stability, reduction of oxidative stress damage caused by alcohol intake, regulation of cytokine levels, and modulation of the gut microbiota. The review also explores potential future research directions and summarizes insights for developing novel therapeutic agents and components. Future prospects: Future research on FPUM for the treatment of ALD could explore promising avenues such as multi-herb combinations, multi-component formulations, and side effect reduction strategies, demonstrating that the development of herbal medicine still holds boundless potential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.