Evidence map›Paper›PMID 40475074›Full record

ReviewRheumatology advances in practice2025

Atherosclerotic cardiovascular disease in systemic lupus erythematosus: from preclinical lupus to atherosclerotic plaque erosion.

Sander I van Leuven, Lenny van Bon, Robin Nijveldt, Amy S Major

Abstract readReview
In one paragraph

Review in Rheumatology advances in practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sander I van LeuvenDepartment of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID https://orcid.org/0000-0003-1432-069X
Lenny van BonDepartment of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands.
Robin NijveldtDepartment of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands.
Amy S MajorDivision of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Funding

Targeting Tfh Cell Metabolic Regulation in SLE and SLE-Associated AtherosclerosisR01AI153167 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MAJOR, AMY S, RATHMELL, JEFFREY C. · 2020 to 2024
$2.8M
NIAID NIH HHS R01 AI153167
6 · The paper itself

Abstract

Patients with systemic lupus erythematosus (SLE) have increased risk of developing atherosclerotic cardiovascular disease (ASCVD). This excessive risk starts to accumulate during the earliest stages of SLE. ASCVD in SLE is associated with an adverse outcome. SLE-enhanced atherogenesis is most likely the consequence of a complex interplay between traditional risk factors and chronic auto-immune inflammation. This underscores the importance of conscientious management of traditional risk factors as well as maintaining low SLE disease activity. Shared immune pathways in SLE and ASCVD can affect the vascular biology of the atherosclerotic process in patients with SLE. In this review, we will discuss how the ASCVD risk evolves during the SLE disease course, and we consider whether patients with SLE are prone to developing superficial erosion of atherosclerotic plaques. This is highly relevant as pilot studies in the general population suggest antithrombotic therapy without stenting could be the better therapeutic approach in patients with plaque erosion.

Indexed as

atherosclerosiscardiovascular diseaseendotheliumplaque erosionplaque rupturesystemic lupus erythematosus

Identifiers

PMID40475074
PMCPMC12137903

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.