Evidence map›Paper›PMID 40475149›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Identification and Validation of New Molecular Subtypes within the Early and Late Mild Cognitive Impairment Stages of Alzheimer's Disease.

Bowei Li, Shashank Yadav, Shu Zhou, Yuheng Du, Leyuan Qian, Zachary Karas, Yueyang Zhang, Li Shen, Jenny J Lee, Badri N Vardarajan and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Bowei LiDepartment of Computational Medicine and Bioinformatics, the University of Michigan. Ann Arbor, MI, USA. 48105.
Shashank YadavDepartment of Computational Medicine and Bioinformatics, the University of Michigan. Ann Arbor, MI, USA. 48105.
Shu ZhouDepartment of Computational Medicine and Bioinformatics, the University of Michigan. Ann Arbor, MI, USA. 48105.
Yuheng DuDepartment of Computational Medicine and Bioinformatics, the University of Michigan. Ann Arbor, MI, USA. 48105.
Leyuan QianDepartment of Biostatistics, the University of Michigan. Ann Arbor, MI, USA. 48109.
Zachary KarasDepartment of Computational Medicine and Bioinformatics, the University of Michigan. Ann Arbor, MI, USA. 48105.
Yueyang ZhangDepartment of Statistics, the University of Michigan. Ann Arbor, MI, USA. 48105.
Li ShenDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, USA 19104.ORCID 0000-0002-5443-0503
Jenny J LeeDepartment of Data Science, Ewha Womans University, Seoul 03760, Republic of Korea.
Badri N VardarajanThe Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University and the New York Presbyterian Hospital, New York, NY, USA. 10032.
Annie J LeeThe Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University and the New York Presbyterian Hospital, New York, NY, USA. 10032.
Lana X GarmireDepartment of Computational Medicine and Bioinformatics, the University of Michigan. Ann Arbor, MI, USA. 48105.
Alzheimer’s Disease Neuroimaging Initiative (ADNI)

Funding

The Health & Aging Brain Study - Health Disparities (HABS-HD)U19AG078109 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI LEIGH A JOHNSON · 2022 to 2026
$181.1M
Peripheral and Central Biomarkers of Alzheimer's Disease in Diverse CohortsU19AG074879 · NIA · MAYO CLINIC JACKSONVILLE · PI Minerva Maria Carrasquillo, NILUFER ERTEKIN-TANER · 2023 to 2026
$42.0M
Research Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Christiane Reitz · 2020 to 2026
$30.1M
Proteogenomics of Cancer Training ProgramT32CA140044 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAO, ARVIND, SARTOR, MAUREEN AGNES · 2010 to 2024
$3.9M
Translational big data analytic approaches to advance drug repurposing for Alzheimer's diseaseR01AG071470 · NIA · UNIVERSITY OF PENNSYLVANIA · PI KIM, DOKYOON, NING, XIA · 2021 to 2025
$3.8M
An Integrative Omics Approach to Identify Biomarkers Related to Preeclampsia and Breast Cancer RisksR01HD084633 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GARMIRE, LANA X · 2016 to 2020
$3.0M
Cancer precision medicine through spatially informative single cell image and transcriptomics data analysisR01LM012373 · NLM · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GARMIRE, LANA X · 2016 to 2024
$2.4M
DR. EPS: Drug Repurposing for Extended Patient SurvivalR01LM012907 · NLM · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GARMIRE, LANA X · 2019 to 2022
$1.0M
Genetic Association Between Alzheimer's Disease and Cardio-Cerebrovascular Risk FactorsK01AG084849 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Annie J Lee · 2024 to 2026
$377k
NCI NIH HHS T32 CA140044NIA NIH HHS K01 AG084849NIA NIH HHS P30 AG066462NIA NIH HHS R01 AG071470NIA NIH HHS U19 AG074879NIA NIH HHS U19 AG078109NICHD NIH HHS R01 HD084633NLM NIH HHS R01 LM012373NLM NIH HHS R01 LM012907
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a heterogeneous neurodegenerative condition. This study identifies clinically relevant new molecular subtypes of the early and late mild cognitive impairment (EMCI and LMCI) stages of AD from 401 patients in the ADNI consortium. Metabolomics and peripheral blood mononuclear cell (PBMC) transcriptomics data are integrated using Similarity Network Fusion (SNF), resulting in two molecular subtypes within EMCI (EMCI-1 and EMCI-2) and LMCI (LMCI-1 and LMCI-2), respectively. Metabolomics, rather than gene expression profiling, is the major contributor to subtyping. Subtype-specific differences in metabolite levels and gene expression correlate with AD pathophysiology, supported by cognitive scores, pseudo-trajectory analysis, and longitudinal dementia diagnoses. The new molecular subtypes are further validated through the EFIGA dataset, and present a clear trend of increase in protein biomarkers including p-Tau181, p-Tau217, A

Indexed as

Alzheimer’s diseasemetabolomicsMild cognitive impairmentMulti-omics integrationSimilarity Network Fusiontranscriptomics

Identifiers

PMID40475149
PMCPMC12140535

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.