Evidence map›Paper›PMID 40475158›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Continuous Assessment of Daily-Living Gait Using Self-Supervised Learning of Wrist-Worn Accelerometer Data.

Yonatan E Brand, Aron S Buchman, Felix Kluge, Luca Palmerini, Clemens Becker, Andrea Cereatti, Walter Maetzler, Beatrix Vereijken, Alison J Yarnall, Lynn Rochester and 4 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Yonatan E BrandSchool of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel.ORCID 0000-0002-4214-0699
Aron S BuchmanRush Department of Neurological Sciences, Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.ORCID 0000-0002-6426-2742
Felix KlugeBiomedical Research, Novartis Pharma AG, Basel, Switzerland.ORCID 0000-0003-4921-6104
Luca PalmeriniDepartment of Electrical, Electronic and Information Engineering Guglielmo Marconi, University of Bologna, Bologna, Italy.
Clemens BeckerRobert Bosch Gesellschaft für Medizinische Forschung, Stuttgart, Germany.
Andrea CereattiDepartment of Electronics and Telecommunications, Politecnico di Torino, Turin, Italy.
Walter MaetzlerDepartment of Neurology, University Medical Center Schleswig-Holstein Campus Kiel, Kiel, Germany.
Beatrix VereijkenDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
Alison J YarnallTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Lynn RochesterTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Silvia Del DinTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Arne MuellerBiomedical Research, Novartis Pharma AG, Basel, Switzerland.
Jeffrey M HausdorffCenter for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Or PerlmanSchool of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel.

Funding

EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
Impaired Gait in Older Adults: Pathologies of Alzheimer's disease and Related DisordersR01AG056352 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BUCHMAN, ARON S · 2017 to 2021
$3.5M
Thinking about walking: Can digital phenotyping of mobility improve the prediction of Alzheimer's dementia and inform on the pathologies and proteins contributing to this association?R01AG079133 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI ARON S BUCHMAN · 2022 to 2026
$3.5M
Using instrumented everyday gait to predict falls in older adults using the WHS cohortR01AG078256 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI I-Min Lee, Peter Michael Wayne · 2023 to 2026
$2.5M
NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG056352NIA NIH HHS R01 AG078256NIA NIH HHS R01 AG079133Wellcome Trust
6 · The paper itself

Abstract

Physical activity and mobility are critical for healthy aging and predict diverse health outcomes. While wrist-worn accelerometers are widely used to monitor physical activity, estimating gait metrics from wrist data remains challenging. We extend ElderNet, a self-supervised deep-learning model previously validated for walking-bout detection, to estimate gait metrics from wrist accelerometry. Validation involved 819 older adults (Rush-Memory- and-Aging-Project) and 85 individuals with gait impairments (Mobilise-D), from six medical centers. In Mobilise-D, ElderNet achieved an absolute error of 8.82 cm/s and an intra-class correlation of 0.87 for gait speed, outperforming state-of-the-art methods (p < 0.001) and models using a lower-back sensor. ElderNet outperformed (percentage error; p < 0.01) competing approaches in estimating cadence and stride length, and better (p < 0.01) classified mobility disability (AUC = 0.80) than conventional gait or physical activity metrics. These results render ElderNet a scalable tool for gait assessment using wrist-worn devices in aging and clinical populations.

Identifiers

PMID40475158
PMCPMC12140532

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.