Evidence mapPaperPMID 40475250Full record

ReviewFrontiers in antibiotics2025

Inclusion of patient-centered, non-microbiological endpoints and biomarkers in tuberculosis drug trials.

Andrew R DiNardo, Wilbert Sabiiti, Stephen H Gillespie, Sophia B Georghiou, Norbert Heinrich, Norbert Hittel, Sami Taghlabi, Danna Carrero Longlax, Mikashmi Kohli, Ursula Panzner and 8 more

Erratum issuedAbstract readReview
In one paragraph

Review in Frontiers in antibiotics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Andrew R DiNardoDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.
Wilbert SabiitiDivision of Infectious Disease and Global Health, University of St Andrews, St Andrews, United Kingdom.
Stephen H GillespieDivision of Infectious Disease and Global Health, University of St Andrews, St Andrews, United Kingdom.
Sophia B GeorghiouFIND, Geneva, Switzerland.
Norbert HeinrichDivision of Infectious Diseases and Tropical Medicine, LMU University Hospital, Munich, Germany.
Norbert HittelOtsuka Novel Products GmbH, Munich, Germany.
Sami TaghlabiThe Global Tuberculosis Program, Texas Children's Hospital, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Danna Carrero LonglaxThe Global Tuberculosis Program, Texas Children's Hospital, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Mikashmi KohliFIND, Geneva, Switzerland.
Ursula PanznerDivision of Infectious Diseases and Tropical Medicine, LMU University Hospital, Munich, Germany.
Collins MusiaGerman Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Borstel, Germany.
Christoph LangeThe Global Tuberculosis Program, Texas Children's Hospital, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Anca VasiliuThe Global Tuberculosis Program, Texas Children's Hospital, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Rob J W ArtsDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.
Anna M MandalakasThe Global Tuberculosis Program, Texas Children's Hospital, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Morten RuhwaldFIND, Geneva, Switzerland.
Lieven J StuyverJanssen Global Public Health R&D, Janssen Pharmaceutica NV, Beerse, Belgium.
Reinout van CrevelDivision of Infectious Disease and Global Health, University of St Andrews, St Andrews, United Kingdom.

Funding

Post-TB epigenetic scars' impact on long-term inflammation, immunity and mortalityR01AI170774 · BAYLOR COLLEGE OF MEDICINE · 2025 to 2025
$721k
NIAID NIH HHS R01 AI170774
6 · The paper itself

Abstract

Tuberculosis drug trials are primarily designed to identify antibiotic regimens with the strongest potency to kill

Indexed as

biomarkercancercardiovascularsequelaetuberculosis

Identifiers

PMID40475250
PMCPMC12140437

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.