ArticleJournal of diabetes and metabolic disorders2025
Hyperglycemia correlated with elevated circulating aminoacylase 1 in patients with pre-diabetes and type 2 diabetes.
Article in Journal of diabetes and metabolic disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Type 2 diabetes is a common metabolic disorder characterized by hyperglycemia and insulin resistance. The metabolism of amino acids is also affected in diabetes, particularly through gluconeogenesis and increased catabolism of branched-chain amino acids. The aminoacylase 1 (ACY-1) enzyme plays a crucial role in the hydrolysis of N-acetylated amino acids, leading to the release of free amino acids. In this study, we aimed to investigate the circulating level of ACY-1 in individuals with type 2 diabetes mellitus (T2DM) and its correlation with glycemic factors. Methods: A total of 30 subjects with T2DM, 30 pre-diabetic individuals, and 30 control subjects were enrolled in the current study. Serum levels of ACY-1 and insulin were measured using ELISA method. Fasting Blood Sugar (FBS), 2-hour Postprandial (2hPP) glucose, HbA1c, urea, and creatinine levels were measured using an auto-analyzer. Insulin resistance was calculated using HOMA-IR formula. Results: We found elevated levels of serum ACY-1 in individuals with diabetes compared to those with pre-diabetes ( Conclusion: Patients with T2DM and individuals with pre-diabetes exhibit elevated serum levels of the aminoacylase-1 enzyme, which correlate with hyperglycemic factors such as FBS, HbA1c, and insulin. This finding underscores the significance of ACY-1 in the pathogenesis and progression of type 2 diabetes.
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