Evidence map›Paper›PMID 40475441›Full record

ArticlebioRxiv : the preprint server for biology2025

Interlocked transcription factor feedback loops maintain and restore touch sensation.

Filipe Marques, Yihan Chen, Honorine Destain, Margaux Marinelli, Paschalis Kratsios

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Filipe MarquesDepartment of Neurobiology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0003-0757-2194
Yihan ChenDepartment of Neurobiology, University of Chicago, Chicago, IL 60637, USA.
Honorine DestainDepartment of Neurobiology, University of Chicago, Chicago, IL 60637, USA.
Margaux MarinelliDepartment of Neurobiology, University of Chicago, Chicago, IL 60637, USA.
Paschalis KratsiosDepartment of Neurobiology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-1363-9271

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Hox-dependent mechanisms for establishment and maintenance of motor neuron terminal identityR01NS116365 · NINDS · UNIVERSITY OF CHICAGO · PI KRATSIOS, PASCHALIS · 2020 to 2024
$2.0M
Molecular mechanisms of motor neuron terminal identityR01NS118078 · NINDS · UNIVERSITY OF CHICAGO · PI KRATSIOS, PASCHALIS · 2020 to 2024
$1.8M
NIH HHS P40 OD010440NINDS NIH HHS R01 NS116365NINDS NIH HHS R01 NS118078
6 · The paper itself

Abstract

The sense of touch relies on the continuous function of specialized mechanosensory circuits, but the underlying molecular mechanisms remain poorly understood. Here, we report that the conserved transcription factors (TFs) CFI-1 (ARID3) and EGL-5 (HOXA7) jointly maintain in adult

Identifiers

PMID40475441
PMCPMC12139737

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.