Evidence map›Paper›PMID 40475476›Full record

ArticlebioRxiv : the preprint server for biology2025

Chronic Treatment of a Mouse Model of Cerebral Amyloid Angiopathy and Brain AT

Natalia Motzko Noto, Lisa S Robison, Robert C Speth

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Natalia Motzko NotoDepartment of Pharmaceutical Sciences, Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.ORCID 0009-0008-6662-0970
Lisa S RobisonDepartment of Psychology and Behavioral Neuroscience, College of Psychology, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.ORCID 0000-0002-5110-9183
Robert C SpethDepartment of Pharmaceutical Sciences, Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.ORCID 0000-0002-6434-2136

Funding

Effects of mild traumatic brain injury in a mouse model of cerebral amyloid angiopathyR03AG081865 · NIA · NOVA SOUTHEASTERN UNIVERSITY · PI ROBISON, LISA SUZANNE · 2023 to 2024
$308k
NIA NIH HHS R03 AG081865
6 · The paper itself

Abstract

Introduction: The renin-angiotensin-aldosterone system (RAAS) has been shown to be dysregulated in dementia, with elevated levels of angiotensin-converting enzyme (ACE), angiotensin (Ang) II, and Ang II type 1 receptors (AT Materials and Methods: Tg-SwDI mice were treated with sub-depressor doses of either telmisartan or lisinopril from 3-8 months of age, with blood pressure being monitored 2 and 4 months after the start of treatment. Postmortem, receptor autoradiography was performed to determine levels of AT Results: No statistically significant differences among groups were observed in any of the 13 regions analyzed. However, trends with medium to large effect sizes were observed. Conclusions: CAA did not significantly dysregulate AT

Indexed as

Cerebral amyloid angiopathylisinoprilreceptor autoradiographytelmisartanTg-SwDI mice

Identifiers

PMID40475476
PMCPMC12139886

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.