In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
13 authors.
Han G KimSepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States.
Marie-Pierre L GauthierDepartment of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, Florida, United States.ORCID 0009-0002-1936-2231 Aidan HiggsNational Institute of Mental Health Intermural Research Program, National Institutes of Health, Bethesda, Maryland United States.ORCID 0000-0003-1602-3381 Denise A HernandezSepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States.
Mingqi ZhouDepartment of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, Florida, United States.ORCID 0000-0002-4605-5467 Jason O BrantDepartment of Biostatistics, College of Public Health & Health Professions, University of Florida, Gainesville, Florida, United States.ORCID 0000-0002-9800-9251 Rhonda L BacherDepartment of Biostatistics, College of Public Health & Health Professions, University of Florida, Gainesville, Florida, United States.ORCID 0000-0001-5787-476X Dijoia B DardenSepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States.ORCID 0000-0001-6022-1014 Shannon M WalletDepartment of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida, United States.ORCID 0000-0003-4650-651X Clayton E MathewsDepartment of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-8817-6355 Philip A EfronSepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States.ORCID 0000-0002-3931-650X Michael P KladdeSepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States.ORCID 0000-0001-7951-9291 Robert MaileSepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States.ORCID 0000-0002-9126-4188 Funding
Multi-modal rescue of pulmonary NRF2-insufficiency after burn and burn + inhalation injury to regulate innate immune dysfunctionR01GM146134 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Robert Maile · 2022 to 2026
$1.6MNIGMS NIH HHS R01 GM146134
6 · The paper itselfAbstract
Severe burn injury induces long-lasting immune dysfunction, but the molecular mechanisms underlying this phenomenon remain unclear. We hypothesized that burn injury leads to epigenetic and transcriptional reprogramming of innate immune cells. Splenic F4/80⁺ macrophages were isolated from mice at days 2, 9, and 14 days post-20% contact burn injury. Targeted transcriptomics and MAPit single-molecule chromatin profiling were used to assess immune, metabolic, and epigenetic changes. Canonical pathway analysis was performed to infer functional shifts over time. Burn injury induced a biphasic response in macrophages. Early after injury (Day 2), there was broad transcriptional suppression and epigenetic silencing of inflammatory regulators, including
Identifiers
PMID40475502
PMCPMC12139774
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