In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
23 authors.
Indy BuiDepartment of Pediatrics, University of California San Diego, La Jolla, CA.
Eric BooneDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA.ORCID 0009-0005-6105-2693 Jacqueline OlnessDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA.ORCID 0009-0006-0602-0127 Sahil PatelDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA.
Colin KernDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA.
Zoey ZhaoDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA.
Ravi S MisraDepartment of Pediatrics, University of Rochester, Rochester, NY.
Zea BorokDivision of Pulmonary, Critical Care, Sleep Medicine and Physiology, Department of Medicine, University of California San Diego, La Jolla, CA.ORCID 0000-0001-8673-8177 Yun ZhangNational Library of Medicine, National Institutes of Health, Bethesda, MD.
Quan ZhuDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA.
James HagoodDepartment of Pediatrics, Children's Research Institute, University of North Carolina, Chapel Hill, NC.ORCID 0000-0003-3938-0330 Xin SunDepartment of Pediatrics, University of California San Diego, La Jolla, CA.
Kun ZhangDepartment of Bioengineering, University of California San Diego, La Jolla, CA.
Gloria S PryhuberDepartment of Pediatrics, University of Rochester, Rochester, NY.
Funding
The University of Rochester's Clinical and Translational Science InstituteUL1TR002001 · NCATS · UNIVERSITY OF ROCHESTER · PI WILSON, KAREN M., ZAND, MARTIN S · 2016 to 2024
$34.6MBioRepository for INvestigation of Diseases of the Lung (BRINDL) - Phase IIIU01HL148861 · NHLBI · UNIVERSITY OF ROCHESTER · PI GLORIA S PRYHUBER · 2019 to 2026
$9.7MThe Human Lung BioMolecular Multi-Scale Atlas Program (HuBMAP-Lung)U54HL165443 · NHLBI · UNIVERSITY OF ROCHESTER · PI PRYHUBER, GLORIA S · 2022 to 2025
$8.0MBiorepository for Investigation of Neonatal Diseases of Lung-Normal (BRINDL-NL)U01HL122700 · NHLBI · UNIVERSITY OF ROCHESTER · PI PRYHUBER, GLORIA S · 2014 to 2018
$6.1MOrgan Specific ProjectU54HL145608 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JAIN, SANJAY, ZHANG, KUN · 2018 to 2021
$5.6MDeveloping Diverse Physician-Investigator Leaders for the Future of Child HealthK12HD105271 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Gabriel G Haddad · 2021 to 2026
$1.8MCell type harmonization of single cell data in HuBMAP and GTExR03OD036499 · OD · J. CRAIG VENTER INSTITUTE, INC. · PI DUPONT, CHRISTOPHER L. · 2023 to 2023
$390kREQUEST OF MERSCOPE FOR SPATIAL TRANSCRIPTOMICSS10OD032391 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZHU, QUAN · 2022 to 2022
$333kNCATS NIH HHS UL1 TR002001NHLBI NIH HHS U01 HL122700NHLBI NIH HHS U01 HL148861NHLBI NIH HHS U54 HL145608NHLBI NIH HHS U54 HL165443NICHD NIH HHS K12 HD105271NIH HHS R03 OD036499NIH HHS S10 OD032391
6 · The paper itselfAbstract
Developing high-resolution reference maps of disease-susceptible spatial niches is a critical step to mitigating the profound effects of lung disease. Here, we present an integrated multimodal single-nucleus human lung atlas (snHLA) profiling 746,047 nuclei from 49 mapped lung blocks spanning clinically relevant distal airways, alveoli, and interstitium across 11 healthy adults. Integrating snRNA-seq and SNARE-seq2, which co-assays chromatin accessibility and gene expression from the same nucleus, we resolved 70 molecularly distinct populations and captured 332,846 accessible chromatin regions, nominating new transcriptional regulators of human lung cell diversity. Spatial transcriptomics using MERFISH mapped 25 cell populations across 7 structural neighborhoods and multiplexed immunofluorescence localized cell subtypes and distal airway-defining protein markers, expanding and validating distinct lung structure-specific cell populations. This open access snHLA and companion Cell Type and Marker Gene Dictionary with anatomically aligned nomenclature delivers a foundational resource at an unprecedented resolution to interrogate the origins of lung pathophysiology.
Identifiers
PMID40475598
PMCPMC12140004
What Socratic holds
Textmetadata
LicenceCC BY
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