Evidence map›Paper›PMID 40475609›Full record

ArticlebioRxiv : the preprint server for biology2025

Synaptic proteins that aggregate and degrade slower with aging accumulate in microglia.

Ian H Guldner, Viktoria P Wagner, Patricia Moran-Losada, Sophia M Shi, Kelly Chen, Barbara T Meese, Hamilton Oh, Yann Le Guen, Nannan Lu, Pui Shuen Wong and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Ian H GuldnerDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Viktoria P WagnerDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Patricia Moran-LosadaDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Sophia M ShiDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Kelly ChenDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Barbara T MeeseChair for Clinical Bioinformatics, Saarland University, Saarbruecken, Germany.
Hamilton OhWu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
Yann Le GuenDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Nannan LuDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Pui Shuen WongBiosciences Central Research Facility, The Hong Kong University of Science and Technology, Hong Kong, China.
Ning-Sum ToHong Kong Center for Neurodegenerative Diseases, Hong Kong, China.
Dylan GarceauThe Jackson Laboratory, Bar Harbor, Maine, USA.
Zimin GuoDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Jian LuoDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Michael SasnerThe Jackson Laboratory, Bar Harbor, Maine, USA.
Andreas KellerChair for Clinical Bioinformatics, Saarland University, Saarbruecken, Germany.
Andrew C YangGladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, USA.
Tom CheungBiosciences Central Research Facility, The Hong Kong University of Science and Technology, Hong Kong, China.
Tony Wyss-CorayDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.

Funding

Targeting Cerebrovascular TGF Signaling in Alzheimer's DiseaseRF1AG059694 · NIA · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI LUO, JIAN, WYSS-CORAY, TONY · 2018 to 2018
$3.0M
Molecular tools to decipher communication across the blood-brain barrierDP5OD033381 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YANG, ANDREW CHRIS · 2022 to 2025
$2.1M
Training Program in Social Neuroscience ResearchT32MH135853 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Hirofumi Morishita, SCOTT JAMES RUSSO · 2024 to 2026
$684k
Studying Neuronal Proteostasis During Aging and AD with Novel Protein Tagging ToolsK99AG088304 · NIA · STANFORD UNIVERSITY · PI GULDNER, IAN HUNTER · 2024 to 2025
$262k
NIA NIH HHS K99 AG088304NIA NIH HHS RF1 AG059694NIH HHS DP5 OD033381NIMH NIH HHS T32 MH135853
6 · The paper itself

Abstract

Neurodegenerative diseases affect 1 in 12 people globally and remain incurable. Central to their pathogenesis is a loss of neuronal protein maintenance and the accumulation of protein aggregates with aging

Identifiers

PMID40475609
PMCPMC12139995

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.