Evidence map›Paper›PMID 40475619›Full record

ArticlebioRxiv : the preprint server for biology2025

Heterogeneous NF-κB activation and enhancer features shape transcription in

Noshin Nawar, Emma Rits, Lianne Cohen, Zeba Wunderlich

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Noshin NawarDepartment of Biomedical Engineering, Boston University, Boston MA 02215, USA.
Emma RitsBiological Design Center, Boston University, Boston, MA 02215, USA.
Lianne CohenBiological Design Center, Boston University, Boston, MA 02215, USA.
Zeba WunderlichDepartment of Biomedical Engineering, Boston University, Boston MA 02215, USA.ORCID 0000-0003-4491-5715

Funding

Synthetic Biology and Biotechnology (SB2) Predoctoral Training ProgramT32GM130546 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHEN, CHRISTOPHER S, KHALIL, AHMAD SAMIR · 2019 to 2023
$1.0M
NIGMS NIH HHS T32 GM130546
6 · The paper itself

Abstract

Conserved NF-κB signaling pathways shape immune responses in animals. In mammals, NF-κB activation patterns and downstream transcription vary with stimulus, cell type, and stochastic differences among identically treated cells. Whether animals without adaptive immunity exhibit similar heterogeneity or rely on distinct immune strategies remains unknown. We engineered

Indexed as

Drosophila immunityImmune-responsive enhancerNF-κBSingle-cell heterogeneity

Identifiers

PMID40475619
PMCPMC12139968

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.