Evidence map›Paper›PMID 40475622›Full record

ArticlebioRxiv : the preprint server for biology2025

Protein Kinase C δ: a critical hub regulating macrophage immunomodulatory functions during

Rudranil Hazra, Mumin Ozturk, Nashied Peton, Tariq Ganief, Sibongiseni Kl Poswayo, Robert P Rousseau, Saiyukthi Naidoo, Shelby-Sara Jones, Anca F Savulescu, Raymond M Moseki and 8 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Rudranil HazraWellcome Discovery Research Platforms in Infections, Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Diseases and Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town, Cape Town 7925, Republic of South Africa.ORCID 0000-0002-4661-9218
Mumin OzturkEpigenomics & Single Cell Biophysics Group, Department of Cell Biology FNWI, Radboud University, Nijmegen, Netherlands.ORCID 0000-0001-9152-7614
Nashied PetonDrug Discovery and Development Centre (H3D), University of Cape Town, Cape Town 7925, Republic of South Africa.ORCID 0000-0001-9128-1247
Tariq GaniefDivision of Chemical, Systems & Synthetic Biology, Institute of Infectious Diseases & Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-3539-9328
Sibongiseni Kl PoswayoDivision of Medical Microbiology, Institute of Infectious Diseases and Molecular Medicine (IDM), Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, Republic of South Africa.ORCID 0000-0002-1532-7124
Robert P RousseauWellcome Discovery Research Platforms in Infections, Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Diseases and Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town, Cape Town 7925, Republic of South Africa.ORCID 0000-0003-1620-1600
Saiyukthi NaidooDivision of Medical Microbiology, Institute of Infectious Diseases and Molecular Medicine (IDM), Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, Republic of South Africa.
Shelby-Sara JonesWellcome Discovery Research Platforms in Infections, Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Diseases and Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town, Cape Town 7925, Republic of South Africa.
Anca F SavulescuDivision of Chemical, Systems & Synthetic Biology, Institute of Infectious Diseases & Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-3428-0157
Raymond M MosekiWellcome Discovery Research Platforms in Infections, Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Diseases and Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town, Cape Town 7925, Republic of South Africa.ORCID 0000-0002-7792-7977
AbhimanyuDepartment of Microbiology, Biological Sciences Division, University of Chicago, Chicago, IL, USA.ORCID 0000-0001-7888-8722
Nelita Du PlessisDSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medical and Health Sciences, Stellenbosch University, Cape Town, Republic of South Africa.ORCID 0000-0001-7881-925X
Jonathan BlackburnDivision of Chemical, Systems & Synthetic Biology, Institute of Infectious Diseases & Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.ORCID 0000-0001-8988-9595
Musa M MhlangaEpigenomics & Single Cell Biophysics Group, Department of Cell Biology FNWI, Radboud University, Nijmegen, Netherlands.ORCID 0000-0003-1381-3409
C Ronald KahnSection of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-7583-9228
Frank BrombacherWellcome Discovery Research Platforms in Infections, Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Diseases and Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town, Cape Town 7925, Republic of South Africa.ORCID 0000-0001-8881-6781
Robert J WilkinsonWellcome Discovery Research Platforms in Infections, Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Diseases and Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town, Cape Town 7925, Republic of South Africa.ORCID 0000-0002-2753-1800
Suraj P PariharWellcome Discovery Research Platforms in Infections, Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Diseases and Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town, Cape Town 7925, Republic of South Africa.ORCID 0000-0002-4932-7990

Funding

Harnessing B cells for TB vaccine development to improve therapy of TB and TB-HIV coinfectionR01AI161013 · NIAID · HACKENSACK UNIVERSITY MEDICAL CENTER · PI GENGENBACHER, MARTIN ALFONS · 2021 to 2025
$6.4M
Insulin-like Growth Factor-1 (IGF-1) signalling in immunometabolism of TB and TB-Diabetes comorbidityK43TW012587 · FIC · UNIVERSITY OF CAPE TOWN · PI Suraj P. Parihar · 2023 to 2026
$450k
FIC NIH HHS K43 TW012587NIAID NIH HHS R01 AI161013Wellcome Trust CC2112
6 · The paper itself

Abstract

A host-modulating candidate gene involved in putative pathogen-killing pathways, with potential novel therapeutic intervention, Protein Kinase C - δ (PKCδ) has been recognized as a critical marker of inflammation with clinical and experimental evidence in recent years. Pulmonary microenvironment during

Identifiers

PMID40475622
PMCPMC12139767

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.