Evidence map›Paper›PMID 40475636›Full record

ArticlebioRxiv : the preprint server for biology2025

RAP1-RHO small GTPase cross-talk mediates integrin-dependent and -independent platelet procoagulant response.

Abigail Ballard-Kordeliski, Nikola Ziegmann, Wyatt Schug, Mark H Ginsberg, Antje Schaefer, Robert H Lee, Wolfgang Bergmeier

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Abigail Ballard-KordeliskiDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, NC, USA.
Nikola ZiegmannDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, NC, USA.
Wyatt SchugDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, NC, USA.
Mark H GinsbergDepartment of Medicine, University of California San Diego, CA, USA.
Antje SchaeferDepartment of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC, USA.
Robert H LeeDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, NC, USA.
Wolfgang BergmeierDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, NC, USA.ORCID 0000-0002-1211-8861

Funding

The Hemostasis, Thrombosis, and Inflammation Models CoreP01HL151433 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Wolfgang Bergmeier · 2020 to 2026
$16.4M
Small GTPases in the biology of platelets and megakaryocytesR35HL144976 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BERGMEIER, WOLFGANG · 2019 to 2025
$5.4M
The Role of the small GTPase Rap1 in Platelet-Coagulation InterplayF31HL165935 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BALLARD, ABIGAIL RENE · 2022 to 2024
$118k
NHLBI NIH HHS F31 HL165935NHLBI NIH HHS P01 HL151433NHLBI NIH HHS R35 HL144976
6 · The paper itself

Abstract

Platelet adhesion and procoagulant activity are critical for primary and secondary hemostasis, respectively. The small GTPase RAP1 is a central regulator of platelet aggregation as it controls αIIbβ3 integrin activation through direct interaction with the integrin adapter protein, TALIN-1 (Tln-1). In addition to their aggregation defect, activated platelets lacking RAP1 (

Identifiers

PMID40475636
PMCPMC12139808

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.