ReviewRegenerative therapy2025
Advancing intestinal disease research using gut-on-a-chip.
Review in Regenerative therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Clinical trials in a dish: cardiometabolic drug development with biological and digital twins.The Journal of clinical investigation · 2026Review
- Intestinal Organoids as Models to Study Viruses: Current Application and Future Perspective.Journal of microbiology and biotechnology · 2026Review
- Biomimetic villi-crypt scaffold-on-chip with tunable mechanical properties for intestinal epithelium modeling.Materials today. Bio · 2026Article
- Modeling human enterovirus A71 infection using an intestinal microphysiological system.Journal of virology · 2026Article
- Organs-on-Chips in Drug Development: Engineering Foundations, Artificial Intelligence, and Clinical Translation.Biosensors · 2026Review
- Infectious Diarrhea in Early Childhood across the Global South: Etiologic Diversity and Pathogenic Mechanisms.ACS infectious diseases · 2026Review
- Transcriptomic profiling reveals substrate- and shear stress-dependent maturation of human small intestinal epithelial cells.Frontiers in pharmacology · 2026Article
- Interface-engineered Caco-2 cell culture on a collagen-coated liquid-liquid interface in a microfluidic device.Beilstein journal of nanotechnology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intestine is exposed constantly to mechanical stimuli, including blood flow or peristalsis. Recently, gut-on-a-chip models have been developed to recapitulate these physiological stresses. In such models, blood flow and peristalsis are simulated by perfusing culture medium through microchannels and applying cyclic suction to vacuum chambers. With these gut-on-a-chips, the effects of mechanical stimuli on the intestinal structure and function have been elucidated. Additionally, gut-on-a-chip models are used to study intestinal diseases, such as infectious diseases, inflammatory bowel disease, and colorectal cancer. Because they accurately recapitulate the pathophysiology of intestinal diseases, research leveraging their use has revealed mechanisms underlying disease onset and progression in the intestine. In this review, we summarize the development of gut-on-a-chip systems and highlight recent research on intestinal diseases using these models.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.