Evidence map›Paper›PMID 40475695›Full record

ArticleRegenerative therapy2025

Therapeutic potential of repaglinide-embedded chitosan hydrogel in promoting wound healing.

Chou-Yi Hsu, Eman Raeed Azzam, Mohammed Merza, Marwah Suliman Maashi, Ahmed Hjazi, Rekha M M, Subhashree Ray, Kapil Ghai, Udaybir Singh, Narges Fereydouni

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Article in Regenerative therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chou-Yi HsuDepartment of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan.
Eman Raeed AzzamMedical Laboratory Techniques Department, College of Health and Medical Technology, University of Al-maarif, Anbar, Iraq.
Mohammed MerzaHawler Medical University, College of Pharmacy, Clinical Analysis Department, Kurdistan Region of Iraq, Erbil, Iraq.
Marwah Suliman MaashiMedical Laboratory Sciences Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Ahmed HjaziDepartment of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
Rekha M MDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to Be University), Bangalore, Karnataka, India.
Subhashree RayDepartment of Biochemistry, IMS and SUM Hospital, Siksha 'O' Anusandhan (Deemed to Be University), Bhubaneswar, Odisha 751003, India.
Kapil GhaiDepartment of Chemistry, Graphic Era Hill University, Dehradun, India.
Udaybir SinghCentre for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, 140401, Punjab, India.
Narges FereydouniNoncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: This study explores the potential of repaglinide-loaded chitosan-based hydrogels (Hy-R1% and Hy-R3%) as multifunctional scaffolds for wound healing applications. It aims to evaluate their physicochemical properties, cytocompatibility, antibacterial activity, and in vivo healing potential. Methods: The hydrogels were prepared by dissolving chitosan in acetic acid, followed by the incorporation of repaglinide. In vitro assessments, including morphology, swelling, degradation, cytocompatibility, and antibacterial activity, were performed. In vivo wound healing was tested in a rat model using full-thickness wounds. Results: Hy-R3% exhibited superior properties in surface morphology, swelling behavior, and degradation rate compared to the control. It also demonstrated the highest cell viability and significant antibacterial activity against Conclusions: Repaglinide-loaded chitosan-based hydrogels, particularly Hy-R3%, represent a promising new therapeutic approach for wound healing. The formulation demonstrated enhanced physicochemical and biological properties, including rapid wound closure and improved tissue regeneration. These findings suggest that repaglinide can be repurposed for wound healing applications, particularly for chronic and diabetic wounds, and lay the foundation for future studies on its broader regenerative potential.

Indexed as

Antibacterial activityChitosan-based hydrogelCytocompatibilityRepaglinideTissue regenerationWound healing

Identifiers

PMID40475695
PMCPMC12138446

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.