ArticleReviews in cardiovascular medicine2025
The Role of Iron and Other Micronutrients in Arterial Stiffness: Univariable and Multivariable Mendelian Randomization.
Article in Reviews in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Prior research on the relationship between iron status and arterial stiffness is limited, with causality still unclear. However, understanding these connections is crucial for improving the prevention and management of arterial stiffness. Therefore, this study aimed to examine the impact of iron status and other micronutrients on arterial stiffness risk using Mendelian randomization (MR) approaches. Methods: MR was performed utilizing genome-wide association studies (GWAS) data from European populations to investigate the causal link between various nutrients (iron, etc.) and arterial stiffness index. We selected the random-effects inverse-variance weighting (IVW) approach for the primary analysis and conducted numerous sensitivity tests to ensure accuracy. Results: This study found a causal effect of genetically predicted high levels of serum iron (β = 0.069, 95% confidence interval (CI) [0.031 to 0.107], Conclusions: This study provides a genetic basis for the causal relationship between elevated iron status and increased arterial stiffness, suggesting the important role of micronutrients in the disease process.
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