ArticleFrontiers in immunology2025
Oral and intratumoral microbiota influence tumor immunity and patient survival.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The oral bacterial microbiota change in oral squamous cell carcinoma: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Microbiota and head and neck cancers: Mechanistic insights and translational potential.Virulence · 2026Review
- Intratumoral Microorganisms in Tumors: Current Understanding and Emerging Therapeutic Strategies.MedComm · 2026Review
- Bacterial extracellular vesicles from Streptococcus mutans drive OSCC progression through β-catenin signaling.Scientific reports · 2026Article
- Cross-disciplinary communication between oral and gut microbiota in head and neck cancer.Frontiers in oncology · 2026Review
- The microbiome-inflammation-immune axis in oral squamous cell carcinoma: from mechanistic insights to therapeutic perspectives.Frontiers in immunology · 2026Review
- Does a link exist between oral microbiota and oral squamous cell carcinoma? A review of current insights.Journal of oral microbiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The aim of this study was to analyze the changes in the oral microbiota of patients with oral squamous cell carcinoma (OSCC) compared to healthy controls and the effect of intratumoral microorganisms on the host immune microenvironment. Methods: Saliva samples were collected from 36 OSCC patients and 34 healthy controls. 16S rDNA sequencing and bioinformatics analysis were conducted on the saliva samples. Differential expression, pathway enrichment, and tumor microenvironment analyses were performed on transcriptome data from head and neck squamous cell carcinoma (HNSCC) in The Cancer Genome Atlas (TCGA) database and OSCC patients in the GEO database. Results: Oral microbiota exhibited comparable α diversity but distinct β diversity between OSCC patients and healthy controls. Conclusion: Specific oral microbiota in OSCC patients may serve as biomarkers for distinguishing OSCC. The interaction between microorganisms and the host alters the tumor immune microenvironment, which provides a theoretical basis for OSCC immunotherapy.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.