ArticleJournal of inflammation research2025
Combined Systemic Immune-Inflammation Index-Prognostic Nutritional Index Score in Evaluating the Prognosis of Patients with Severe Community-Acquired Pneumonia.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Early ΔNLR Outperforms Baseline Inflammatory Markers in Predicting Short-Term Outcomes in Sepsis.Diagnostics (Basel, Switzerland) · 2026Article
- Research status and hotspots of the systemic immune-inflammation index: A bibliometric analysis.Medicine · 2026Article
- Stroke-Associated Pneumonia and Impaired Functional Recovery After Stroke: The Role of Nutritional-Inflammatory Factors.Advances in respiratory medicine · 2026Article
- Combined nutritional and inflammatory risk stratification for predicting functional outcomes in acute ischemic stroke.Frontiers in nutrition · 2026Article
- Predictive value of the systemic immune-inflammation index combined with the prognostic nutritional index for postoperative recurrence in early-stage cervical cancer: evidence from a multicenter cohort study.Frontiers in oncology · 2026Article
- Risk warning of systemic immune-inflammation index and coagulation parameters for hospital-acquired pneumonia in patients with traumatic brain injury.American journal of translational research · 2026Article
- A Risk Prediction Model for MDRJournal of multidisciplinary healthcare · 2026Article
- Systemic Inflammatory Indices (SII and SIRI) in 30-Day Mortality Risk Stratification for Community-Acquired Pneumonia: A Study Alongside CURB-65 and PSI.Pathogens (Basel, Switzerland) · 2025Article
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Authors and funding
6 authors.
Funding
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Abstract
Background: While both the systemic immune-inflammation index (SII) and prognostic nutritional index (PNI) have demonstrated prognostic value in various diseases, the clinical utility of their combined score (SII-PNI) for predicting outcomes in patients with severe community-acquired pneumonia (SCAP) remains incompletely understood. The aim of this study is to explore the predictive value of SII-PNI score in patients with SCAP. Methods: We conducted a retrospective analysis of the clinical data of 138 patients diagnosed with SCAP. The SII, PNI, and the SNII-PNI score were calculated. Receiver operating characteristic (ROC) curve analysis was performed to determine the optimal threshold of SII-PNI. Multivariable logistic regression models were used to assess the association between the SII-PNI score and 28-day mortality. Results: The cutoff values for predicting 28-day mortality were >4689.82 for SII and <32.18 for PNI, respectively, with sensitivities of 59.1% and 60.3% and specificities of 85.3% and 68.2%. Multivariate analysis reveals that a SII-PNI score of 2 (OR, 14.11; 95% CI, 3.18-62.66; p = 0.001) was independently associated with a high risk of 28-day mortality. Conclusion: Our results indicate that a higher SII-PNI score at admission was linked to poor prognosis in SCAP patients. The combined SII-PNI score can effectively help clinicians assess disease progression and optimize risk assessment and clinical management for SCAP patients.
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