Evidence map›Paper›PMID 40475987›Full record

Observational studyFrontiers in endocrinology2025

Prior COVID-19 infection increases degenerated oocytes but does not affect IVF outcomes: a prospective cohort study.

Huijun Chen, Hongxin Guo, Qi Zhao, Yuan Li, Ge Lin, Philipp Kalk, Berthold Hocher, Fei Gong

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huijun Chen *Institute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Hongxin Guo *Institute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Qi ZhaoInstitute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Yuan LiInstitute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Ge LinInstitute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Philipp KalkDepartment of Nephrology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Berthold HocherInstitute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Fei GongInstitute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Science, Central South University, Changsha, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The global health crisis of coronavirus disease 2019 (COVID-19) continues to impact people of all age groups worldwide. Recent studies increasingly support that COVID-19 infection may affect reproductive function, causing subfertility and infertility. It is a prospective observational cohort study conducted in the Reproductive and Genetic Hospital of CITIC-Xiangya. 781 women recovered from COVID-19 and 388 uninfected controls undergoing IVF treatment. All participants received standard IVF treatment. Oocyte and embryo quality parameters and pregnancy outcomes were analyzed. Primary outcomes were oocyte and embryo quality, secondary outcomes included clinical pregnancy rates. Results: The results show that the COVID-19 recovery group had a higher number of degenerated oocytes compared to controls (0.15 ± 0.40 Conclusion: Our study indicates that prior COVID-19 infection is associated with a slightly increased risk of degenerated oocytes but does not significantly impact other IVF outcomes or subsequent pregnancy rates. The time interval post-infection does not appear to influence IVF outcomes, suggesting no need to delay treatment following COVID-19 recovery. These findings provide reassurance for women planning IVF after COVID-19 infection.

Indexed as

COVID-19Fertilization in VitroInfertility, FemaleOocytesAdultFemaleHumansPregnancyPregnancy OutcomePregnancy RateProspective StudiesSARS-CoV-2embryo qualityoocyte qualitypost-COVID-19pregnancy outcomestime interval

Identifiers

PMID40475987
PMCPMC12137096

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.