Evidence map›Paper›PMID 40476256›Full record

ReviewNPJ dementia2025

Non-coding variation in dementias: mechanisms, insights, and challenges.

Brianne B Rogers, J Nicholas Cochran

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in NPJ dementia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Functional Analysis of Late-Onset Alzheimer's Disease Risk Genes inbioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Brianne B RogersHudsonAlpha Institute for Biotechnology, Huntsville, AL USA.
J Nicholas CochranHudsonAlpha Institute for Biotechnology, Huntsville, AL USA.

Funding

UAB Alzheimer's Disease Research CenterP30AG086401 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Erik D Roberson · 2024 to 2026
$17.1M
US-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative ResearchR01AG057234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Claudia Duran-Aniotz, Agustin M. Ibanez · 2019 to 2026
$6.1M
Towards Generating a Multimodal and Multivariate Classification Model from Imaging and Non-Imaging Measures for Accurate Diagnosis and Monitoring of Dementia in Parkinsons disease.R01NS117547 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MISHRA, VIRENDRA R · 2020 to 2024
$3.6M
Identification of trans-regulatory elements controlling MAPT transcriptionR01AG085357 · NIA · HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY · PI Jesse N Cochran, Richard M Myers · 2024 to 2026
$2.2M
NIA NIH HHS P30 AG086401NIA NIH HHS R01 AG057234NIA NIH HHS R01 AG085357NINDS NIH HHS R01 NS117547
6 · The paper itself

Abstract

Dementia encompasses many neurodegenerative disorders. While some causal coding variants are known, most GWAS variants are in non-coding regions of the genome, making understanding functional impacts challenging. This review explores the role of non-coding variation in dementia, covering methods to identify enhancers and their target genes, prioritize GWAS variants, and validate the functional effects of variation, providing a comprehensive framework for investigating non-coding variation and its implications in dementia research.

Indexed as

DementiaGeneticsNeurodegenerationNeurodegenerative diseases

Identifiers

PMID40476256
PMCPMC12133568

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.