Evidence map›Paper›PMID 40476381›Full record

ArticleJournal of medicinal chemistry2025

Design and Synthesis of Novel PET Radiotracers for Imaging Sphingosine-1-Phosphate Receptor 5 (S1PR5) in the Brain.

Jiawen Lang, Wenjuan Zhou, Tianyu Huang, Hao Jiang, Hong Chen, Shuxian Xu, Lin Qiu, Madison Heady, Yanbo Yu, Matthew R Brier and 4 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jiawen LangDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Wenjuan ZhouDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Tianyu HuangDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.ORCID 0000-0002-5607-4901
Hao JiangDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Hong ChenDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Shuxian XuDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Lin QiuDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.ORCID 0000-0001-8823-4132
Madison HeadyDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Yanbo YuDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Matthew R BrierDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Ying-Hwey NaiDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Caroline GuglielmettiDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Joel S PerlmutterDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Zhude TuDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.ORCID 0000-0003-0325-835X

Funding

Training/DisseminationP41EB025815 · NIBIB · WASHINGTON UNIVERSITY · PI Robert J. Gropler · 2018 to 2026
$12.7M
PET SPHINGOSINE-1-PHOSPHATE RECEPTOR 1 (S1PR1) RADIOTRACERS FOR MULTIPLE SCLEROSISR01NS103988 · NINDS · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger, Zhude Tu · 2017 to 2026
$5.3M
PET PROBES FOR IMAGING THE VESICULAR ACETYLCHOLINE TRANSPORTERR01NS075527 · NINDS · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2011 to 2021
$4.9M
Neuroimaging of PDE10AR01NS103957 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES, TU, ZHUDE · 2017 to 2021
$3.1M
Investigate neuroinflammation in the brain of PD using S1P1 radioligandsR01NS134586 · NINDS · WASHINGTON UNIVERSITY · PI JOEL Synes PERLMUTTER, Zhude Tu · 2024 to 2026
$1.8M
DEVELOPING PET AGENTS FOR IMAGING PHOSPHODIESTERASE 10A (PDE10A)R33MH092797 · NIMH · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2013 to 2015
$1.5M
Acquisition of high-resolution PET/CT preclinical imaging instrument at MIRS10OD030403 · OD · WASHINGTON UNIVERSITY · PI SHOGHI, KOORESH ISAAC · 2021 to 2021
$929k
NIBIB NIH HHS P41 EB025815NIH HHS S10 OD030403NIMH NIH HHS R33 MH092797NINDS NIH HHS R01 NS075527NINDS NIH HHS R01 NS103957NINDS NIH HHS R01 NS103988NINDS NIH HHS R01 NS134586
6 · The paper itself

Abstract

Sphingosine-1-phosphate receptor-5 (S1PR5) is highly expressed in oligodendrocytes and it plays an important role in neurodegenerative disorders like multiple sclerosis. We designed, synthesized, and determined the binding potencies of 27 novel S1PR5 ligands. Four radiotracers [

Indexed as

BrainDrug DesignPositron-Emission TomographyRadiopharmaceuticalsSphingosine-1-Phosphate ReceptorsAnimalsFluorine RadioisotopesHumansMaleMiceMice, Inbred C57BLRatsFluorine RadioisotopesRadiopharmaceuticalsSphingosine-1-Phosphate Receptors

Identifiers

PMID40476381
PMCPMC13225913

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.