Evidence mapPaperPMID 40478312Full record

ReviewHead and neck pathology2025

Etiopathogenesis of Oral Lichen Planus: A Review.

Gabriel Bassan Marinho Maciel, Taline Laura Guse, Roberto Marinho Maciel, Cristiane Cademartori Danesi

Abstract readReview
In one paragraph

Review in Head and neck pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gabriel Bassan Marinho MacielDepartment of Pathology, Federal University of Santa Maria, Av. Roraima, 1000, Santa Maria, Rio Grande do Sul, 97015-900, Brazil. gabrielbmmaciel@yahoo.com.br.ORCID http://orcid.org/0000-0001-6045-4109
Taline Laura GuseGraduate Program in Dental Sciences, Federal University of Santa Maria, Santa Maria, Rio Grande do Sul, Brazil.ORCID http://orcid.org/0009-0008-5998-7010
Roberto Marinho MacielDepartment of Pathology, Federal University of Santa Maria, Av. Roraima, 1000, Santa Maria, Rio Grande do Sul, 97015-900, Brazil.ORCID https://orcid.org/0000-0001-6954-0388
Cristiane Cademartori DanesiDepartment of Pathology, Federal University of Santa Maria, Av. Roraima, 1000, Santa Maria, Rio Grande do Sul, 97015-900, Brazil.ORCID https://orcid.org/0000-0001-9170-5791

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOral lichen planus (OLP) is a chronic immune-mediated disease affecting the mucous membranes of the oral cavity, regarded as a potentially malignant disorder.

methodsWe performed a narrative review of the literature compiling key hypotheses on the etiopathogenesis of OLP, addressing recently raised aspects and questions yet to be elucidated.

resultsThe etiopathogenesis of OLP is complex and not fully understood, with evidence suggesting a multifactorial cause. Lesions appear to be triggered by the recognition of one or more antigens, provoking a dysregulated T-cell-mediated immune response against oral keratinocytes. Genetic and environmental factors significantly influence the orchestration of various immune and non-immune cells, cytokines, and molecules involved in this pathological process.

conclusionsUnderstanding recent theories on the etiopathogenesis of OLP is crucial forguiding future research on its diagnosis and treatment, as well as on preventing its malignant transformation.

Indexed as

Lichen Planus, OralHumansApoptosisInflammationLichen planus, oralMouth neoplasmsPyroptosis

Identifiers

PMID40478312
PMCPMC12144021

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.