Evidence map›Paper›PMID 40479068›Full record

ArticleScience advances2025

The metabolite itaconate is a transcriptional and posttranslational modulator of plant metabolism, development, and stress response.

Tao Zhang, Amman Klair, Ziyao Tang, Abigail Tripka, Shihong Luo, Andres V Reyes, Jihyeon Lee, Katreena Gundran, Sarah E Noll, Xuanzhi Wang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Genomes of nitrogen-fixing eukaryotes reveal an alternate path for organellogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Tao ZhangCell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-3024-9128
Amman KlairCell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0009-0008-5974-5281
Ziyao TangCollege of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Abigail TripkaCell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0009-0008-1123-2110
Shihong LuoCell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0009-0001-1647-3094
Andres V ReyesDepartment of Plant Biology, Carnegie Institute of Science, Stanford, CA 94305, USA.ORCID 0000-0001-8761-802X
Jihyeon LeeCell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA.
Katreena GundranCell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA.
Sarah E NollDepartment of Chemistry, Stanford University, Stanford, CA 94305, USA.ORCID 0009-0005-1115-4712
Xuanzhi WangState Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing 100871, China.
Richard N ZareDepartment of Chemistry, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0001-5266-4253
Shou-Ling XuDepartment of Plant Biology, Carnegie Institute of Science, Stanford, CA 94305, USA.ORCID 0000-0002-6741-9506
Adriana Garay-ArroyoLaboratorio de Genética Molecular, Desarrollo y Evolución de Plantas, Depto. de Ecología Funcional, Instituto de Ecología, Universidad Nacional Autónoma de México, Ciudad de México, México.ORCID 0000-0003-1575-6284
Chu WangCollege of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.ORCID 0000-0002-6925-1268
Alexandra J DickinsonCell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-7840-5636

Funding

Nutrient regulation of Alternative splicing and transcription by O-GlcNAcylationR01GM135706 · NIGMS · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI XU, SHOULING · 2020 to 2024
$1.8M
Thermo Orbitrap Eclipse Tribrid with ETD and an Ultimate 3000 RSLCnano SystemS10OD030441 · OD · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI XU, SHOULING · 2022 to 2022
$600k
NIGMS NIH HHS R01 GM135706NIH HHS S10 OD030441
6 · The paper itself

Abstract

Itaconate, derived from the tricarboxylic acid cycle, is recognized as a key regulator of the immune response in mammals. Despite this well-characterized role, its presence and functions within plants have remained largely unexplored. Here, we identify itaconate as an endogenous metabolite in maize and

Indexed as

ArabidopsisGene Expression Regulation, PlantPlant DevelopmentProtein Processing, Post-TranslationalStress, PhysiologicalSuccinatesTranscription, GeneticZea maysPlant RootsSeedlingsitaconic acidSuccinates

Identifiers

PMID40479068
PMCPMC12143382

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.