Evidence map›Paper›PMID 40479809›Full record

ReviewCurrent opinion in neurobiology2025

Experience-dependent control of synaptic remodeling and structural plasticity by glia.

Dominic J Vita, Austin Ferro, Lucas Cheadle

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dominic J VitaCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Austin FerroCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Lucas CheadleCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA; Howard Hughes Medical Institute, Cold Spring Harbor, NY 11724, USA. Electronic address: cheadle@cshl.edu.

Funding

Neuroimmunological insights into brain development and dysfunction: an integrative approach focused on microglial dynamicsDP2MH132943 · NIMH · COLD SPRING HARBOR LABORATORY · PI CHEADLE, LUCAS M · 2022 to 2025
$2.9M
Synapse Engulfment by Oligodendrocyte Precursor Cells: A New Mechanism of Circuit Refinement in the Developing BrainR01NS131486 · NINDS · COLD SPRING HARBOR LABORATORY · PI Lucas M Cheadle · 2023 to 2026
$2.5M
NIMH NIH HHS DP2 MH132943NINDS NIH HHS R01 NS131486
6 · The paper itself

Abstract

The central nervous system (CNS) integrates intrinsic molecular cues with sensory experience to shape synaptic connectivity between neurons. Once established, these emergent neural circuits remain plastic into adulthood to facilitate behavioral adaptations to changes in the sensory landscape. While sensory experience has been recognized as a major contributor to synaptic wiring since the foundational work of Hubel and Wiesel in the mid-1900s, the field has only recently begun to uncover the roles of nonneuronal cells, or glia, in experience-dependent aspects of synaptic refinement and remodeling. Herein, we review recent work demonstrating that many glial cell types-including invertebrate glia, astrocytes, microglia, and oligodendrocyte-lineage cells-participate in the experience-dependent remodeling of neural circuits across the lifespan.

Indexed as

NeurogliaNeuronal PlasticitySynapsesAnimalsHumans

Identifiers

PMID40479809
PMCPMC12762845

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.