ArticleNeuroImage2025
Cardiometabolic state links neurovascular burden with brain structure and function: Evidence from EEG and MRI.
Article in NeuroImage, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- White matter hyperintensities are associated with locus coeruleus atrophy and astrocytic βAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Perceived socioeconomic vulnerability, but not objective poverty, is linked to interoception through perceived stress.Frontiers in psychology · 2026Article
- Creative experiences and brain clocks.Nature communications · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Aging affects brain structure and function alongside metabolic and vascular processes leading to energetic impairments. While local neurometabolic dysfunction in aging is well-documented, the influence of systemic cardiometabolic and vascular markers on brain structure and function remains less understood. We examine the link between cardiometabolic dysfunction (measured by an allostatic load index) and neurovascular burden (measured by white matter hyperintensities), and their associations with brain changes, including ventricular and hippocampal volume, as well as EEG activity, across the adult lifesplan. Analyzing data from 196 healthy individuals across ages (20-75 years), we found a significant positive correlation between allostatic load index and white-matter hyperintensities, irrespective of age. White matter hyperintensities are also positively linked with ventricular enlargement, but not hippocampal atrophy. The allostatic load index mediated the relationship between white-matter hyperintensities and ventricular volume. Regarding brain function, changes in the spectral aperiodic exponent but not periodic alpha power were linked to white matter hyperintensities and the allostatic load index. The allostatic load index also mediated the relationship between spectral aperiodic exponent and white matter hyperintensities. Thus, findings suggest that the cardiometabolic state, as measured by the allostatic load index, plays a crucial role in brain health in aging, particularly influencing ventricular enlargement and increased aperiodic activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.