Evidence map›Paper›PMID 40480642›Full record

ArticleJournal of agricultural and food chemistry2025

Advanced Microbiome Therapeutics Accelerate MASLD Recovery by Restoring Intestinal Microbiota Equilibrium and the Gut-Liver Axis in a Mouse Model.

Johnson Lok, Congjia Chen, Valeria Iannone, Ambrin Farizah Babu, Emily Kwun Kwan Lo, Ruben Vazquez-Uribe, Troels Holger Vaaben, Mikko Kettunen, Otto Savolainen, Ursula Schwab and 5 more

Abstract read
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In one paragraph

Article in Journal of agricultural and food chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Johnson LokSchool of Medicine, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio 70210, Finland.
Congjia ChenSchool of Biological Sciences, University of Hong Kong, Pokfulam, Hong Kong SAR 999077, China.ORCID 0009-0004-6800-3184
Valeria IannoneSchool of Medicine, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio 70210, Finland.
Ambrin Farizah BabuSchool of Medicine, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio 70210, Finland.
Emily Kwun Kwan LoSchool of Biological Sciences, University of Hong Kong, Pokfulam, Hong Kong SAR 999077, China.
Ruben Vazquez-UribeTechnical University of Denmark, The Novo Nordisk Foundation Center for Biosustainability, Kongens Lyngby 2800, Denmark.
Troels Holger VaabenTechnical University of Denmark, The Novo Nordisk Foundation Center for Biosustainability, Kongens Lyngby 2800, Denmark.
Mikko KettunenBiomedical Imaging Unit, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio 70211, Finland.
Otto SavolainenSchool of Medicine, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio 70210, Finland.
Ursula SchwabSchool of Medicine, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio 70210, Finland.
Morten Otto Alexander SommerTechnical University of Denmark, The Novo Nordisk Foundation Center for Biosustainability, Kongens Lyngby 2800, Denmark.ORCID 0000-0003-4005-5674
Kati HanhinevaSchool of Medicine, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio 70210, Finland.
Marjukka KolehmainenSchool of Medicine, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio 70210, Finland.
Hani El-NezamiSchool of Medicine, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio 70210, Finland.
Carlos Gómez-GallegoSchool of Medicine, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio 70210, Finland.ORCID 0000-0003-0219-1827

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbiota dysbiosis and endocrine dysregulation are key players in metabolic dysfunction-associated steatotic liver disease (MASLD) development. This study evaluated whether advanced microbiome therapeutics can restore intestinal microbial equilibrium and gut-liver axis balance during MASLD recovery. MASLD was induced in mice using a high-fat, high-sugar diet, and then shifted to a standard diet, where intervention groups received engineered

Indexed as

Fatty LiverGastrointestinal MicrobiomeLiverAnimalsBacteriaDisease Models, AnimalDysbiosisEscherichia coliHumansMaleMiceMice, Inbred C57BLaldaferminE. coli Nissle 1917fibroblast growth factor 19insulin-like growth factor 1integrative multiomicsnonalcoholic fatty liver disease (NAFLD)

Identifiers

PMID40480642
PMCPMC12186743

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.