Evidence mapPaperPMID 40481016Full record

ArticleScientific reports2025

Multiscale investigation of collagen structure in human skin and gel matrices using polarization resolved second harmonic generation microscopy.

Mengyao Zhou, Madalena Pinto Gomes, Anouk Elgersma, H Ibrahim Korkmaz, Bouke K H L Boekema, Marie Louise Groot

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mengyao ZhouFaculty of Science, Department of Physics, Laserlab, Vrije Universiteit Amsterdam, De Boelelaan 1105, 1081HV, Amsterdam, The Netherlands. m.zhou@vu.nl.
Madalena Pinto GomesDepartment of Plastic Reconstructive and Hand Surgery, Amsterdam Movement Sciences (AMS) Institute, Amsterdam UMC, location VUmc, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Anouk ElgersmaAlliance of Dutch Burn Care, Burn Research Lab, 1941 AJ, Beverwijk, The Netherlands.
H Ibrahim KorkmazDepartment of Plastic Reconstructive and Hand Surgery, Amsterdam Movement Sciences (AMS) Institute, Amsterdam UMC, location VUmc, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Bouke K H L BoekemaDepartment of Plastic Reconstructive and Hand Surgery, Amsterdam Movement Sciences (AMS) Institute, Amsterdam UMC, location VUmc, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Marie Louise GrootFaculty of Science, Department of Physics, Laserlab, Vrije Universiteit Amsterdam, De Boelelaan 1105, 1081HV, Amsterdam, The Netherlands. m.l.groot@vu.nl.

Funding

China Scholarship Council 202006970016European Union's Horizon 2020 research and innovation program Marie-Curie Grant agreement number 955722
6 · The paper itself

Abstract

Collagen is critical to the structure and function of skin tissues, with the collagen I/III ratios influencing fibrillogenesis, fiber organization, and skin mechanics. Abnormal collagen organization, such as in fibrosis or scar tissue, compromises both skin functionality and aesthetics. In this study, we employed label-free polarization resolved second harmonic generation (PSHG) microscopy to investigate collagen structure in artificial collagen matrices with various Col I/III ratios at the fibril scale (

Indexed as

CollagenCollagen Type ICollagen Type IIISecond Harmonic Generation MicroscopySkinCicatrixHumansMicroscopy, PolarizationCollagenCollagen Type ICollagen Type IIICollagen gelCollagen type I and type IIIPolarization second harmonic generationScar skin

Identifiers

PMID40481016
PMCPMC12144187

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.