ArticleNature ecology & evolution2025
A single-cell atlas of the bobtail squid visual and nervous system highlights molecular principles of convergent evolution.
Article in Nature ecology & evolution, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Visual computation in the cephalopod brain.Current opinion in neurobiology · 2026Review
- Multiplexed gene expression analysis in dissociated and intact planarian flatworm tissues using in situ hybridization chain reaction.Biology open · 2026Article
- Evolution of compound eye cell types shapes visual behaviors acrossbioRxiv : the preprint server for biology · 2026Article
- Conserved dopaminergic system in Octopus minor: molecular characterization and spatial expression.Brain structure & function · 2026Article
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- Rapid mid-Cretaceous diversification of squid and cuttlefish preceded radiation into coastal niches.Nature ecology & evolution · 2026Article
- DuplicatedBiology · 2025Article
- A non-invasive method to genotype cephalopod sex by quantitative PCR.bioRxiv : the preprint server for biology · 2025Article
- Genome reorganisation and expansion shape 3D genome architecture and define a distinct regulatory landscape in coleoid cephalopods.bioRxiv : the preprint server for biology · 2025Article
- Invertebrate glial barriers as a model for understanding blood-brain barrier evolution.Fluids and barriers of the CNS · 2025Review
- Why sequence the genome of every species? A view from evolutionary biology.Journal of the Marine Biological Association of the United Kingdom. Marine Biological Association of the United Kingdom · 2025Article
- Cellular-resolution gene expression mapping reveals organization in the head ganglia of the gastropod, Berghia stephanieae.The Journal of comparative neurology · 2024Article
- Biological Sunglasses in a Deep-Sea Squid: Pigment Migration in the Retina ofVision (Basel, Switzerland) · 2024Article
- Gene modelling and annotation for the Hawaiian bobtail squid, Euprymna scolopes.Scientific data · 2024Article
- Cephalopod-omics: Emerging Fields and Technologies in Cephalopod Biology.Integrative and comparative biology · 2023Article
- Marine Invertebrates One Cell at A Time: Insights from Single-Cell Analysis.Integrative and comparative biology · 2023Review
- Emerging questions on the mechanisms and dynamics of 3D genome evolution in spiralians.Briefings in functional genomics · 2023Review
- Single-cell transcriptomics refuels the exploration of spiralian biology.Briefings in functional genomics · 2023Review
- The neural basis of visual processing and behavior in cephalopods.Current biology : CB · 2023Review
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Authors and funding
11 authors.
Funding
Abstract
The cephalopod and vertebrate visual systems are a textbook example of convergent evolution with unknown molecular underpinnings. Here we characterize 98,537 single-cell transcriptomes in the bobtail squid Euprymna berryi to understand how the cephalopod retina and optic lobes relate to the vertebrate retina. We confirm the overall relative simplicity of the cephalopod retina but identify two related photoreceptor cell subtypes expressing distinct r-opsins. By contrast, the adult optic lobe contains a diverse repertoire of neuronal and glial cell types, with a predominance of dopaminergic neurons. We show that cephalopod-specific gene duplicates probably contributed to this cell type diversification. Comparing neuronal cell population in the optic lobes of hatchlings and adults, we reveal a switch towards dopaminergic neurotransmitter usage with age, indicative of a maturation process. We further identify an FMRF-amide-based retrograde signal from the optic lobe towards the retina that supports the functional analogy of the cephalopod optic lobe cortex and the vertebrate inner retina in visual signal processing from a molecular standpoint. Finally, comparative analyses with vertebrate and arthropod cells suggest a scenario in which two photoreceptor types and two neuronal populations may have already been present in the eye of the bilaterian ancestor.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.