ArticlePediatric research2026
Retinal changes in children with Familial Mediterranean Fever: the effect of chronic subclinical inflammation.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Retinal clues to subclinical inflammation in familial Mediterranean fever.Pediatric research · 2026Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn Familial Mediterranean Fever (FMF), acute-phase reactants rise during attacks, indicating active inflammation. However, subclinical inflammation-present even during remission-may contribute to organ damage, including ocular involvement. This study aimed to investigate the effects of subclinical chronic inflammation on ocular structures in children with FMF.
methodsThe study involved 51 pediatric FMF patients in remission for at least three months and healthy controls. Spectral domain optical coherence tomography (SD-OCT) was used to measure intraocular pressure, axial length, peripapillary retinal nerve fiber layer (RNFL) thickness, central macular thickness, and subfoveal choroidal thickness.
resultsAcute-phase reactant levels were significantly elevated in the FMF group (p < 0.001). Inferotemporal RNFL thickness was notably reduced (p = 0.008), along with central macular, subfoveal, nasal, and temporal choroidal thicknesses. A mild positive correlation was observed between proteinuria and axial length (r = 0.282, p = 0.045).
conclusionSubclinical inflammation in FMF may lead to early structural changes in the eye, potentially progressing over time. These findings highlight the importance of long-term ophthalmologic monitoring in pediatric FMF patients to better understand the cumulative impact of persistent inflammation. IMPACT: This study assessed peripapillary RNFL thickness and choroidal vascular structure in children with FMF using SD-OCT to evaluate ocular effects of subclinical inflammation. It was found that chronic inflammation may lead to thinning of the retina and choroid even in children with relatively short disease duration. Peripapillary RNFL thickness was reduced in the temporal inferior quadrant and correlated with serum amyloid levels; additionally, choroidal thickness was significantly lower in the patient group, suggesting early ocular involvement and its potential as a marker of subclinical systemic inflammation.
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Registered trials
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