ArticleEuropean journal of medical research2025
CBL-mediated AQP1 ubiquitination aggravates kidney-yang deficiency syndrome by promoting lipid metabolism dysregulation.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveKidney-Yang Deficiency Syndrome (KYDS) is associated with lipid metabolism dysregulation. This study aimed to investigate the effect of casitas B-lineage lymphoma (CBL)-mediated aquaporin 1 (AQP1) ubiquitination on KYDS.
methodsThe KYDS rat model was induced via intraperitoneal injection of hydrocortisone. Body weight, body temperature, sperm motility, serum hormone levels, organ indices, and histopathological changes of rats were evaluated. AQP1 was knocked down to detect the effect of AQP1 on lipid metabolism in KYDS rats. Immunofluorescence and immunoprecipitation were used to verify the relationship between CBL and AQP1, and CBL knockdown KYDS rats were constructed to test the effect of CBL on AQP1 ubiquitination.
resultsAQP1 expression was downregulated in KYDS rats. Knockdown of the AQP1 gene in KYDS rats resulted in decreased body weight, body temperature, sperm motility, and testicular index, along with increased renal index. It also resulted in changes of serum hormone levels and exacerbated pathologic changes. Additionally, AQP1 knockdown further suppressed lipid accumulation in KYDS rats, as evidenced by reductions in lipid droplets and the expression of lipid synthesis proteins. Intriguingly, elevated expression of CBL was observed in KYDS, and its knockdown inhibited the ubiquitin-mediated degradation of AQP1. The inhibition of CBL in KYDS improved lipid metabolism dysregulation, thereby ameliorating KYDS.
conclusionCBL-mediated AQP1 ubiquitination aggravates KYDS by promoting lipid metabolism dysregulation, offering promising insights for targeted therapeutic interventions.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.