Evidence map›Paper›PMID 40481552›Full record

ArticleInflammation and regeneration2025

Genetic deletion of microsomal prostaglandin E synthase-1 promotes imiquimod-induced psoriasis in mice.

Fumiaki Kojima, Yuka Hioki, Miori Sumida, Yoshiko Iizuka, Hitoshi Kashiwagi, Kei Eto, Shiho Arichi, Shotaro Maehana, Makoto Kubo, Haruhito A Uchida and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammation and regeneration, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Fumiaki Kojima *Department of Pharmacology, Kitasato University School of Allied Health Sciences, 1-15-1 Kitasato, Minami-Ku, Sagamihara, 252-0373, Japan. kojimaf@kitasato-u.ac.jp.ORCID http://orcid.org/0000-0002-5160-1493
Yuka Hioki *Department of Pharmacology, Kitasato University School of Allied Health Sciences, 1-15-1 Kitasato, Minami-Ku, Sagamihara, 252-0373, Japan.
Miori SumidaDepartment of Pharmacology, Kitasato University School of Allied Health Sciences, 1-15-1 Kitasato, Minami-Ku, Sagamihara, 252-0373, Japan.
Yoshiko IizukaRegenerative Medicine and Cell Design Research Facility, Kitasato University School of Allied Health Science, 1-15-1 Kitasato, Minami-Ku, Sagamihara, 252-0373, Japan.
Hitoshi KashiwagiFaculty of Pharmaceutical Sciences, Hokkaido University, Kita 12-Jo, Nishi 6-Chome, Kita-Ku, Sapporo, 060-0812, Japan.
Kei EtoRegenerative Medicine and Cell Design Research Facility, Kitasato University School of Allied Health Science, 1-15-1 Kitasato, Minami-Ku, Sagamihara, 252-0373, Japan.
Shiho ArichiDepartment of Physiology, Kitasato University School of Allied Health Sciences, 1-15-1 Kitasato, Minami-Ku, Sagamihara, 252-0373, Japan.
Shotaro MaehanaRegenerative Medicine and Cell Design Research Facility, Kitasato University School of Allied Health Science, 1-15-1 Kitasato, Minami-Ku, Sagamihara, 252-0373, Japan.
Makoto KuboRegenerative Medicine and Cell Design Research Facility, Kitasato University School of Allied Health Science, 1-15-1 Kitasato, Minami-Ku, Sagamihara, 252-0373, Japan.
Haruhito A UchidaDepartment of Chronic Kidney Disease and Cardiovascular Disease, Faculty of Medicine, Dentistry, and Pharmaceutical Science, Okayama University, 2-5-1 Shikata-Cho, Kita-Ku, Okayama, 700-8558, Japan.
Takafumi IchikawaDepartment of Regulation Biochemistry, Kitasato University Graduate School of Medical Sciences, 1-15-1 Kitasato, Minami-Ku, Sagamihara, 252-0373, Japan.

Funding

JSPS KAKENHI 21K06603Kitasato University Graduate School of Medical Sciences Student Research Program 2022-2023Kitasato University School of Allied Health Sciences Research Project 2021-1017Regenerative Medicine and Cell Design Research Facility Research Program 2024School of Allied Health Sciences, Kitasato University Research Project 2022-1008School of Allied Health Sciences, Kitasato University Research Project 2023-1004School of Allied Health Sciences, Kitasato University Research Project 2024-1003
6 · The paper itself

Abstract

backgroundPsoriasis is a chronic inflammatory disease associated with abnormalities in the immune system. Microsomal prostaglandin E synthase-1 (mPGES-1), a terminal enzyme for prostaglandin (PG) E

methodsPsoriasis was induced in mPGES-1-deficient (mPGES-1

resultsThe inflamed skin of mPGES-1

conclusionsOur study results demonstrate that mPGES-1 is the main enzyme responsible for skin PGE

Indexed as

CyclooxygenaseImmunityInflammationInterleukin-17 AProstaglandin E2Prostaglandin E synthasePsoriasisγδ T cell

Identifiers

PMID40481552
PMCPMC12142878

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.