Evidence map›Paper›PMID 40482397›Full record

ReviewCurrent opinion in neurobiology2025

Decoding neuronal diversity: Mechanisms governing neural cell fate in Drosophila.

Asif Bakshi, Khaled Ben El Kadhi, Claude Desplan

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Asif BakshiCenter for Genomics and Systems Biology (CGSB), New York University Abu Dhabi, PO Box 129188, Abu Dhabi, United Arab Emirates.
Khaled Ben El KadhiCenter for Genomics and Systems Biology (CGSB), New York University Abu Dhabi, PO Box 129188, Abu Dhabi, United Arab Emirates.
Claude DesplanCenter for Genomics and Systems Biology (CGSB), New York University Abu Dhabi, PO Box 129188, Abu Dhabi, United Arab Emirates; Department of Biology, New York University, 100 Washington Place, New York, NY 10003, USA. Electronic address: cd38@nyu.edu.

Funding

Stochastic choices in the retina and optic lobesR01EY013010 · NEI · NEW YORK UNIVERSITY · PI DESPLAN, CLAUDE · 1999 to 2025
$9.1M
Neurogenesis of the optic lobesR01EY017916 · NEI · NEW YORK UNIVERSITY · PI Claude Desplan · 2007 to 2026
$8.0M
NEI NIH HHS R01 EY013010NEI NIH HHS R01 EY017916
6 · The paper itself

Abstract

Generating neuronal diversity from a limited number of neural stem cells is fundamental for the proper functioning of the brain. However, the mechanisms that govern neural fate determination have long been elusive due to the intricate interplay of multiple independent factors that influence a cell's commitment to specific fates. While classical genetics and labeling tools have laid the groundwork for identifying cell types and understanding neural complexity, recent breakthroughs in single-cell transcriptomics and whole-brain connectomics represent a significant advancement in enabling a comprehensive characterization of brain cell types and the underlying mechanisms that encode these neuronal identities. This review focuses on recent developments in our understanding of neural cell fate determination in Drosophila, emphasizing three key mechanisms: spatial patterning, temporal patterning, and neuron-type specific terminal selector transcription factors.

Indexed as

BrainCell DifferentiationCell LineageDrosophilaNeural Stem CellsNeurogenesisNeuronsAnimals

Identifiers

PMID40482397
PMCPMC12353183

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.