ArticleNPJ systems biology and applications2025
Changes in epistatic green-beard alleles induce domain shift in hypostatic rock-paper-scissors-like green-beard competition.
Article in NPJ systems biology and applications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Fraternal cooperation of hierarchical cancer parallels metazoan multicellularity and eusociality.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Engineered kin recognition specificities in the TraA cell surface receptor.The ISME journal · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Myxobacteria with compatible TraA receptors can exchange materials located on the outer membrane. Such outer membrane exchange (OME) is an efficient strategy to help clonemates. If OME occurs between cells carrying different sitAI repertoires, however, transferred toxins may harm the recipient. While traA and sitAI can be categorized as green-beard genes, the functionality of sitAI is heavily reliant on traA. In other words, the harming effect of the sitAI is invalidated without OME. Hence, I termed traA and sitAI epistatic and hypostatic green-beard genes, respectively, and proposed a handshake-dependent rock-paper-scissors-like (RPSL) model. The simulation results imply that evolutionary pressure for traA diversification is context-dependent. The competition among aggressors, susceptibles, and freeloaders determined by hypostatic sitAI repertoire exhibits cyclic dominance, yet involves the possibility of divergent dynamics. By changing the epistatic green-beard traA alleles, susceptibles can avoid invasion of the aggressors, establishing another domain of the RPSL competition (domain shift). Furthermore, I mathematically analyzed the expected relatedness between myxobacteria from the compatibility of epistatic and hypostatic green-beard alleles. Not only can it explain the polymorphism of myxobacterial traA and sitAI alleles, but the model can also be expanded to investigate the social interactions of fusogenic cancer cells.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.