Evidence map›Paper›PMID 40483513›Full record

ArticleStem cell research & therapy2025

KRT5

Jiasheng Chen, Mingming Yu, Lin Wang, Hua Xie, Yiqing Lv, Yichen Huang, Yue Hong, Fang Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiasheng Chen *Department of Urology, School of Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University, 355 Luding Road, Shanghai, 200062, PR China.
Mingming Yu *Department of Urology, School of Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University, 355 Luding Road, Shanghai, 200062, PR China.ORCID http://orcid.org/0000-0001-9957-6568
Lin WangDepartment of Urology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, PR China.
Hua XieDepartment of Urology, School of Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University, 355 Luding Road, Shanghai, 200062, PR China.
Yiqing LvDepartment of Urology, School of Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University, 355 Luding Road, Shanghai, 200062, PR China.
Yichen HuangDepartment of Urology, School of Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University, 355 Luding Road, Shanghai, 200062, PR China. huangyc@shchildren.com.cn.
Yue HongStem Cell Center, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, PR China. yuehongsls@hainanu.edu.cn.
Fang ChenDepartment of Urology, School of Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University, 355 Luding Road, Shanghai, 200062, PR China. chenfang01@sjtu.edu.cn.ORCID http://orcid.org/0000-0002-0242-331X

Funding

National Natural Science Foundation of China 82270702National Natural Science Foundation of China 82300762Science and Technology Innovation Plan Of Shanghai Science and Technology Commission 23YF1435100
6 · The paper itself

Abstract

backgroundUrothelial regeneration is a crucial part of bladder tissue engineering. However, there is a lack of ideal "seed cells" in current practices. Here, we demonstrated that a sub-population of p63 positive basal cells could be activated and differentiate into intermediate and superficial umbrella cells after full-thickness mucosal resection in rabbit.

methodsA focal mucosal resection model was used to characterize the role of different urothelial cells during regeneration. Urothelial basal cells were isolated from rabbit bladder mucosa and cultured in vitro. The basal cells were then transplanted in vivo in a manner of cell sheet for reconstruction.

resultsVia single-cell RNA sequencing (scRNA-seq), it has been confirmed that the cluster of KRT5

conclusionsIn summary, bioengineering urothelium with KRT5

Indexed as

Keratin-5RegenerationTranscription FactorsUrinary BladderUrotheliumAnimalsCell DifferentiationRabbitsTissue EngineeringKeratin-5Transcription FactorsBladder urothelium regenerationCapsule vascular bedCell sheetTissue engineeringUrothelial basal cell

Identifiers

PMID40483513
PMCPMC12145601

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.