Evidence map›Paper›PMID 40483575›Full record

ArticleMolecular oncology2025

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl-x

Cécilia Thomine, Sterenn Guillemot, Louis-Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain and 1 more

Abstract read
In one paragraph

Article in Molecular oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cécilia ThomineUniversité de Caen Normandie, Inserm, Anticipe U1086, Interdisciplinary Research Unit for the Prevention and Treatment of Cancer, BioTICLA Laboratory (Precision Medicine for Ovarian Cancers), Caen, France.
Sterenn GuillemotUniversité de Caen Normandie, Inserm, Anticipe U1086, Interdisciplinary Research Unit for the Prevention and Treatment of Cancer, BioTICLA Laboratory (Precision Medicine for Ovarian Cancers), Caen, France.
Louis-Bastien WeiswaldUniversité de Caen Normandie, Inserm, Anticipe U1086, Interdisciplinary Research Unit for the Prevention and Treatment of Cancer, BioTICLA Laboratory (Precision Medicine for Ovarian Cancers), Caen, France.
Romane FlorentUniversité de Caen Normandie, Services Unit PLATON, ORGAPRED Core Facility, Caen, France.
Edwige AbeilardUniversité de Caen Normandie, Inserm, Anticipe U1086, Interdisciplinary Research Unit for the Prevention and Treatment of Cancer, BioTICLA Laboratory (Precision Medicine for Ovarian Cancers), Caen, France.
Florence GiffardUniversité de Caen Normandie, Inserm, Anticipe U1086, Interdisciplinary Research Unit for the Prevention and Treatment of Cancer, BioTICLA Laboratory (Precision Medicine for Ovarian Cancers), Caen, France.
Emilie BrotinUniversité de Caen Normandie, Services Unit PLATON, ImpedanCELL Core Facility, Caen, France.
Mélanie BriandUniversité de Caen Normandie, Inserm, Anticipe U1086, Interdisciplinary Research Unit for the Prevention and Treatment of Cancer, BioTICLA Laboratory (Precision Medicine for Ovarian Cancers), Caen, France.
Enora DolivetUniversité de Caen Normandie, Inserm, Anticipe U1086, Interdisciplinary Research Unit for the Prevention and Treatment of Cancer, BioTICLA Laboratory (Precision Medicine for Ovarian Cancers), Caen, France.
Laurent PoulainUniversité de Caen Normandie, Inserm, Anticipe U1086, Interdisciplinary Research Unit for the Prevention and Treatment of Cancer, BioTICLA Laboratory (Precision Medicine for Ovarian Cancers), Caen, France.
Marie VilledieuUniversité de Caen Normandie, Inserm, Anticipe U1086, Interdisciplinary Research Unit for the Prevention and Treatment of Cancer, BioTICLA Laboratory (Precision Medicine for Ovarian Cancers), Caen, France.ORCID 0000-0002-7747-1279

Funding

Institut National de la Santé et de la Recherche MédicaleLigue Contre le Cancer, Seine-Maritime CommitteeMinistère chargé de l'Enseignement Supérieur et de la RechercheRégion NormandieUniversité de Caen Normandie
6 · The paper itself

Abstract

Identifying innovative therapeutic strategies is crucial to improve clinical management of ovarian cancer. Previously, we showed that ovarian cancer cell apoptosis can be triggered by inhibiting the anti-apoptotic proteins Bcl-x

Indexed as

Antineoplastic Agentsbcl-X ProteinHistone Deacetylase InhibitorsHydroxamic AcidsMyeloid Cell Leukemia Sequence 1 ProteinOvarian NeoplasmsSulfonamidesApoptosisCell Line, TumorDrug SynergismFemaleHumansAntineoplastic AgentsBCL2L1 protein, humanbcl-X ProteinbelinostatHistone Deacetylase InhibitorsHydroxamic AcidsMCL1 protein, humanMyeloid Cell Leukemia Sequence 1 ProteinSulfonamidesBcl‐xL inhibitorHDAC inhibitorMcl‐1 inhibitorovarian cancertargeted therapy

Identifiers

PMID40483575
PMCPMC12591309

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.