Evidence map›Paper›PMID 40483705›Full record

ArticleClinical transplantation2025

Hepatitis C Nucleic Acid Test Positive (NAT+) Solid Organ Consent Rates Are Highest in Patients Listed for Liver Transplant and With an English Language Preference.

Sachiko M Oshima, Alice Parish, Jacqueline B Henson, Mariya Samoylova, Donna Niedzwiecki, Lisa McElroy, Lindsay King, Julius M Wilder, Kara Wegermann

Abstract read
In one paragraph

Article in Clinical transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sachiko M OshimaDivision of Gastroenterology, Department of Medicine, Duke University Health System, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0001-8015-4058
Alice ParishDepartment of Biostatistics & Bioinformatics, Duke University, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0002-5775-0457
Jacqueline B HensonDivision of Gastroenterology, Department of Medicine, Duke University Health System, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0003-3488-6615
Mariya SamoylovaDepartment of Surgery, Duke University Health System, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0003-3119-2781
Donna NiedzwieckiDepartment of Biostatistics & Bioinformatics, Duke University, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0002-3566-0450
Lisa McElroyDepartment of Surgery, Duke University Health System, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0003-2366-2579
Lindsay KingDivision of Gastroenterology, Department of Medicine, Duke University Health System, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0001-9426-2682
Julius M WilderDivision of Gastroenterology, Department of Medicine, Duke University Health System, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0001-7962-2053
Kara WegermannDivision of Gastroenterology, Department of Medicine, Duke University Health System, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0002-1024-9040

Funding

Increasing Access to Transplant through Improved Clinical Decision MakingK08MD017632 · NIMHD · DUKE UNIVERSITY · PI Lisa M McElroy · 2022 to 2026
$551k
Duke Department of Medicine Stead Resident Research GrantDuke Division of Gastroenterology Dawn Provenzale AwardNIMHD NIH HHS K08 MD017632
6 · The paper itself

Abstract

backgroundTransplantation of hepatitis C virus (HCV) nucleic acid (NAT) positive organs is associated with shorter time to transplant and decreased risk of death on the waiting list. Treatment for HCV post-transplant is well-tolerated, successful, and leads to similar transplant outcomes to patients transplanted with HCV NAT- organs. Despite these outcomes, not all patients consent to receive HCV NAT+ organs, and factors associated with consent are not well-known.

methodsThis retrospective single-center study of adult patients listed for heart, liver, lung, and kidney transplant aimed to determine whether sociodemographic and organ-specific disparities exist in consent for HCV NAT+ donor organs.

resultsOf 2788 transplant candidates, 44% (N = 1229) consented to receive an HCV NAT+ organ. Patients who designated English as their preferred language were more likely to consent compared to a non-English preference (45% vs. 19%, p < 0.001). Consent rates were highest amongst patients listed for liver transplantation compared to kidney, heart, and lung transplants (67%, N = 319 vs. 42%, N = 602 vs. 38%, N = 159 vs. 32%, N = 149; p < 0.001).

conclusionsOverall, more efforts are needed to ensure that all patients who may benefit from consenting for HCV NAT+ organs are appropriately educated in their language of choice on the risks and benefits.

Indexed as

HepacivirusHepatitis CInformed ConsentLanguageLiver TransplantationOrgan TransplantationRNA, ViralTissue and Organ ProcurementTissue DonorsWaiting ListsAdultFemaleFollow-Up StudiesHumansMaleMiddle AgedRNA, Viraldisparitieshepatitis Cinfection and infectious agentsliver diseaseorgan allocationtransplant social workerviral

Identifiers

PMID40483705
PMCPMC13200718

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.