Evidence map›Paper›PMID 40485780›Full record

ReviewAsian journal of neurosurgery2025

Is It Safe to Use Tranexamic Acid for Chronic Subdural Hematoma: A Systematic Review and Meta-Analysis.

Mohammad Amin Habibi, Seyed Ahmad Naseri Alavi, Amir Reza Boskabadi, Farid Qoorchi Moheb Seraj, Mohammad Sina Mirjnani, Mohsen Benam, Firooz Salehpour, Andrew J Koets

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Asian journal of neurosurgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohammad Amin HabibiDepartment of Neurosurgery, Tehran University of Sciences, Shariati Hospital, Tehran, Iran.
Seyed Ahmad Naseri AlaviDepartment of Neurosurgery, School of Medicine, Emory University, Atlanta, Georgia, United States.ORCID 0000-0002-3602-4966
Amir Reza BoskabadiMashhad University of Medical Sciences, Mashhad, Iran.
Farid Qoorchi Moheb SerajDepartment of Neurosurgery, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad Sina MirjnaniStudent Research Committee, Qom University of Medical Sciences, Qom, Iran.
Mohsen BenamDepartment of Neurological Surgery, UT Southwestern Medical Center, Dallas, Texas, United States.
Firooz SalehpourDepartment of Neurosurgery, Tabriz University of Medical Sciences, Tabriz Iran.
Andrew J KoetsDepartment of Neurological Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, United States.ORCID 0000-0001-9169-2230

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trans-4-(aminomethyl)-cyclohexane-1-carboxylic acid, also known as tranexamic acid (TXA), has occasionally been used to prevent postoperative recurrence of chronic subdural hematoma (CSDH) after burr hole craniotomy (BC). However, there is a lack of data about the safety and efficacy of TXA administration after BC. This systematic review and meta-analysis adhered to the Cochrane Handbook Standards Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and searching databases up to January 2024 for randomized controlled trials and cohort studies evaluating TXA. The primary outcome was CSDH recurrence and reoperation. The secondary outcome was thrombosis risk and mortality rate. Ten studies were included, comprising 14,836 patients with CSDH who underwent surgical treatment. Five studies were randomized controlled trials, while the other two case series and three cohort studies. The overall pooled hematoma recurrence rate in the group of patients who used TXA as an adjuvant treatment to the surgical intervention (TXA group), compared with patients who only used surgery to treat CSDH (control group), was 0.05 (95% confidence interval [0.03-0.08],

Indexed as

chronic subdural hematomacraniotomysubdural hematomatranexamic acid

Identifiers

PMID40485780
PMCPMC12136966

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.