ReviewJournal of clinical and experimental dentistry2025
Salivary and gingival crevicular fluid (GCF) protein biomarkers as proxies of root resorption following orthodontic tooth movement. A systematic review.
Review in Journal of clinical and experimental dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Biomarkers for Treatment Response in Orthodontics: Molecular Mechanisms, Clinical Utility, and Future Directions.International journal of molecular sciences · 2026Review
- Cytokines as Key Drivers of Pathological Root Resorption: Integrating Molecular Mechanisms, Genetic Determinants, and Biomarker-Based Insights.Biomedicines · 2026Review
- Oxidative stress and antioxidant pathways in the pathogenesis of periodontitis and peri-implantitis: mechanistic insights and therapeutic potentials.Frontiers in oral health · 2026Review
- Change in the concentration of interleukin-10 and tumor necrosis factor-α in gingival crevicular fluid after probiotic use in patients undergoing treatment with fixed orthodontic appliances : A prospective case-control study.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Orthodontically induced root resorption (OIRR) is a common complication of orthodontic treatment, characterized by inflammatory and remodeling processes. This systematic review (SR) aimed to evaluate the potential of salivary and gingival crevicular fluid (GCF) biomarkers as proxies for the early detection of an ongoing root resorption process during orthodontic tooth movement. Material and Methods: Electronic searches were performed in multiple databases of published and grey literature, up to May 2023. Eligible studies included participants undergoing orthodontic treatment with reported biomarkers linked to root resorption against a control group. Analysis methods of the biomarkers such as ELISA, Western Blot, mass spectrometry, were utilized. Results: Seven studies met the inclusion criteria, with sample sizes ranging from 19 to 74 participants and varied study designs, with methodological heterogeneity. The detected proteins and biomarkers were dentin phosphoryn, dentin sialoprotein, dentin sialophosphoprotein, fetuin-A, IFN- γ, IL-10, IL-12p70, IL-7 p21-ARC, sIgA and these served as promising indicators of increased root resorption activity, during orthodontic treatment. Conclusions: Biomarkers and proteins in saliva and GCF demonstrated a potential for early detetction and monitoring of OIRR, offering a non-invasive alternative to radiographic techniques. However, standardization of protein and biomarker assessment protocols and development of large-scale studies seem imperative.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.